Lexa Thomas has never quite fit in. Having grown up in a family of blondes while more closely resembling Constance Wu, she's neither White enough nor Asian enough. Visiting her father in Taiwan as a child, Lexa thought she'd finally found a place where she belonged. But that was years ago, and even there, some never truly considered her to be a part of the family. When her estranged father dies unexpectedly, leaving the fate of his Taiwanese family in Lexa's hands, she is faced with the choice to return to Taiwan and claim her place in her heritage.

Years of trying unsuccessfully to conceive a child have broken more than Angie DeSaria’s heart. Following a painful divorce, she moves back to her small Pacific Northwest hometown and takes over management of her family’s restaurant. In West End, where life rises and falls like the tides, Angie’s fortunes will drastically change yet again when she meets and befriends a troubled young woman.

Clare and Henry have known each other since Clare was six and Henry was 36. They were married when Clare was 23 and Henry was 31. Impossible but true, because Henry is one of the first people diagnosed with Chrono-Displacement Disorder: periodically his genetic clock resets and he finds himself misplaced in time, pulled to moments of emotional gravity from his life, past and future. His disappearances are spontaneous, his experiences unpredictable, alternately harrowing and amusing.

Patrick, or Gay Uncle Patrick (GUP, for short), has always loved his niece, Maisie, and nephew, Grant. That is, he loves spending time with them when they come out to Palm Springs for weeklong visits, or when he heads home to Connecticut for the holidays. But in terms of caretaking and relating to two children, no matter how adorable, Patrick is, honestly, overwhelmed. So when tragedy strikes and Maisie and Grant lose their mother and Patrick's brother has a health crisis of his own, Patrick finds himself suddenly taking on the role of primary guardian.

Emma London never thought she had anything in common with her grandmother Genevieve London. The regal old woman came from wealthy and bluest-blood New England stock, but that didn't protect her from life's cruelest blows. Genevieve rose from the ashes of grief and built a fashion empire that was respected the world over, even when it meant neglecting her other son. When Emma's own mother died, her father abandoned her on his mother's doorstep. Genevieve took Emma in and reluctantly raised her - until Emma got pregnant her senior year of high school.

Alison has never been a fan of Christmas. But with it right around the corner and her husband busily decorating their cozy Vermont home, she has no choice but to face it. Then she gets the call. Mavis, Alison’s estranged mother, has been diagnosed with cancer and has only weeks to live. She wants to spend her remaining days with her daughter’s family. But Alison grew up with her mother’s alcoholism and violent abuse and is reluctant to unearth these traumatic memories.

Selena Murphy is commuting home on the train when she strikes up a conversation with a beautiful stranger in the next seat. The woman introduces herself as Martha and soon confesses that she’s been stuck in an affair with her boss. Selena, in turn, confesses that she suspects her husband is sleeping with the nanny. When the train arrives at Selena’s station, the two women part ways, presumably never to meet again.

Intimacy has always eluded 27-year-old Maggie Krause - despite being brought up by married parents, models of domestic bliss - until, that is, Lucia came into her life. But when Maggie’s mom, Iris, dies in a car crash, Maggie returns home only to discover a withdrawn dad, an angry brother, and, along with Iris' will, five sealed envelopes, each addressed to a mysterious man she’s never heard of. In an effort to run from her own grief and discover the truth about Iris - who made no secret of her discomfort with her daughter's sexuality - Maggie embarks on a road trip.

Jen and Riley have been best friends since kindergarten. As adults, they remain as close as sisters, though their lives have taken different directions. Jen married young, and after years of trying, is finally pregnant. Riley pursued her childhood dream of becoming a television journalist and is poised to become one of the first Black female anchors of the top news channel in their hometown of Philadelphia. But the deep bond they share is severely tested when Jen’s husband, a city police officer, is involved in the shooting of an unarmed Black teenager.

Unruly Red knows she’s no one’s idea of a sweet old granny. But with one long-distance phone call, the fortysomething bar owner with the tattoos and tight jeans is suddenly responsible for two young grandchildren she hardly knows.

It’s been 17 years since the tragic summer the McAvoy sisters fell apart. Lindy, the wild one, left home, carved out a new life in the city, and never looked back. Delia, the sister who stayed, became a mother herself, raising her daughters and running the family shop in their small Ohio hometown on the shores of Lake Erie. But now, with their mother’s ailing health and a rebellious teenager to rein in, Delia has no choice but to welcome Lindy home.

In an idyllic Los Angeles neighborhood, where generations enjoy deep roots in old homes, the O’Rourke family fits right in. Miriam and Craig are both artists and their four children carry on the legacy. When their teenage son, Nick, is diagnosed with schizophrenia, a tumultuous decade ensues in which the family careens off the conventional course. Like the 10 Biblical plagues, they are hit by one catastrophe after another: violence, evictions, arrests, a suicide attempt, a near-drowning - even cancer and a brain tumor - play against the backdrop of a wild teenage bacchanal.

For Sasha, summer means time at her family's sprawling old house out on Long Island. For Ray, it's the same. Sasha and Ray aren't related - and they've never met - but long ago, before they were born, Sasha's dad and Ray's mom were married. Then came a bitter divorce, remarriages, and a new generation of children. Now, the two families have an arrangement: use the summerhouse at your designated time and never cross paths. Sasha and Ray do connect, though, by email - joking around, confiding in one another, forming a friendship.

Annie Beyers has everything - a beautiful house, a loving husband, and an adorable daughter. It’s a day like any other when she takes Hannah to the pediatrician…until she wakes hours later from a car accident. When she asks for her daughter, confused doctors tell Annie that Hannah never existed. In fact, nothing after waking from the crash is the same as Annie remembers. Five happy years of her life apparently never happened.

Whitney had some misgivings when she dropped her increasingly moody teenage daughter, Amelia, off at Lauren’s house. She’d never met the parents, and usually she’d go in, but Amelia clearly wasn’t going to let something so humiliating happen, so instead Whitney waved to her daughter before pulling away from the little house with the roses in front. But when she goes back the next day, an elderly couple answers the door - Amelia and Lauren aren’t there, and this couple swears they never were, that she’s at the wrong house.