• AAD Late Breaking Results from FLEX-UP with Dr. Melinda Gooderham and Dr. Angela Law

  • Apr 7 2025
  • Length: 19 mins
  • Podcast

AAD Late Breaking Results from FLEX-UP with Dr. Melinda Gooderham and Dr. Angela Law

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  • Episode: Do I start at 15 or jump straight to 30? Key Questions Answered: What’s the translational takeaway for dermatologists?🩺Do these findings reassure you about dose escalation or reduction?🤔15 mg vs. 30 mg-clinic conundrum solved🏷️🌴☀️ Sunshine, palm trees, and late-breaking dermatology data!🎙️💡 In this special live episode of the Skin and Joints Podcast, from the AAD 2025 in sunny Orlando, Florida, we breakdown the FLEX UP late breaking trial results for upadacitinib for moderate to severe atopic dermatitis with with two leading Canadian dermatologists: Dr. Melinda Gooderham and Dr. Angela Law!They also share their ultimate “conference flexes” We go beyond EASI, spotlighting itch control 🤲, quality of life, and real-world relevance 🏥 for all those asking, “So what does this mean practically?Together, our experts explore how this flexible dosing study answers a longstanding question: Should you start patients on the 15 mg or 30 mg dose, and can you switch between them for better results?Hear how this late-breaking data might recalibrate your go-to prescribing assessment and whether it’s time to tweak your approach.The discussion pokes at the trial’s design, why Week 12 and 24 were selected, the importance of itch reduction, and safety data. Dr. Gooderham and Dr. Law also weigh in on how these findings might—or might not—revolutionize current clinical practice. Learning ObjectivesFLEX UP Trial Design & RationaleGrasp how the study was structured to evaluate flexible dosing of upadacitinib at 15 mg and 30 mg.Clinical Efficacy MeasuresUnderstand the role of EASI 90, NRS, and quality-of-life metrics in gauging patient outcomes.Real-World ImplicationsExamine how FLEX UP data supports practical dosing choices—starting big or small—and equips you to address patient questions about switching doses.Safety & TolerabilitySummarize the key safety findings (including VTE, serious infections, and zoster) and how they align with existing JAK-inhibitor data.Future DirectionsRecognize the need for longer-term follow-up and additional analyses to further refine flexible dosing strategies and patient selection.🌞 Grab a comfy pair of sneakers 👟 and a protein bar 🍫 because we’re tackling front-line, day-to-day dilemmas in AD management—once and for all! Expect wit, warmth, and wisdom in this fast-paced chat, complete with palm trees, protein bars, and plenty of pro tips. ABOUT DR. MELINDA GOODERHAMDermatologist, Peterborough, ON Dr. Melinda Gooderham is a well-established dermatologist who serves as medical director at the SKiN Centre for Dermatology and the principal investigator for the SKiN Research Centre. Dr. Gooderham received her MD from the University of Western Ontario in 1999 and then completed her Dermatology residency at the University of Toronto in 2004. Before training in medicine, Dr. Gooderham obtained a Bachelor of Science degree from Queen’s University in Kingston in 1992 and a Master of Science degree from the University of Guelph in 1995. Dr. Gooderham is an Assistant Professor at Queens University and works as a Consultant Physician at the Peterborough Regional Health Centre (PRHC). A fellow of the Royal College of Physicians and Surgeons of Canada, she has investigated over 200 clinical trials focusing on inflammatory skin diseases, including psoriasis and atopic dermatitis. Beyond clinical practice, Dr. Gooderham actively contributes to dermatology publications as an author, reviewer, and associate editor, with authorship of over 200 articles. Her passion for education extends to global audiences through engaging lectures on innovative therapies for skin diseases. About DR. ANGELA LAW MD, FRCPCDermatologist | VANCOUVER, BCDr. Angela Law is a board certified Dermatologist in both Canada and the United States. She completed her dermatology residency in a joint program at the University of Saskatchewan and Dalhousie University. She is a Clinical Instructor in the Department of Dermatology and Skin Science at UBC, regularly teaching medical students and residents, and runs the Urgent Dermatology Clinic at Mount Saint Joseph’s Hospital. She also has an active dermatology practice in downtown Vancouver.Dr. Law also runs the Vulvar Dermatology Clinic at Mount Saint Joseph’s Hospital which is an innovative clinic with a focus on Women’s Health within Providence Health Care.Episode supported by Abbvie.📻www.skinandjoints.ca✉️info@skinandjoints.ca 📻www.skinandjoints.ca✉️info@skinandjoints.ca
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