• The Lay of the Land: Overview of Biology of HER2 in Genitourinary, Gastrointestinal, and Gynecologic Malignancies

  • Apr 21 2025
  • Length: 14 mins
  • Podcast

The Lay of the Land: Overview of Biology of HER2 in Genitourinary, Gastrointestinal, and Gynecologic Malignancies

  • Summary

  • In this episode, Zev A. Wainberg, MD; Funda Meric-Bernstam, MD; Alexandra Leary, MD, PhD; and Catherine Fahey, MD, PhD, explore testing for HER2 alterations and the incidence of HER2-positive disease in the treatment of genitourinary, gastrointestinal, and gynecologic malignancies.

    • HER2 Testing in Advanced Cancers: Recommendations for when and how to test for HER2 in advanced cancers and how these tests guide therapy selection
    • Variability in HER2 Expression Across Tumor Types: Insights into the heterogeneity of HER2 expression and amplification in different cancers
    • Challenges in Standardizing HER2 Testing: The complexities of scoring and testing HER2 in different cancers and institutions, and the need for better harmonization of guidelines and approaches

    Presenters:
    Zev A. Wainberg, MD
    Professor of Medicine and Surgery
    Co-Director of GI Oncology
    Director, Early Phase Clinical Research Program
    Jonsson Comprehensive Cancer Center
    UCLA School of Medicine
    Los Angeles, California

    Funda Meric-Bernstam, MD
    Chair, Department of Investigational Cancer Therapeutics
    Medical Director, Institute for Personalized Cancer Therapy
    Nellie B. Connally Chair in Breast Cancer
    The University of Texas MD Anderson Cancer Center
    Houston, Texas

    Alexandra Leary, MD, PhD
    President, GINECO Group
    Co-Director, Department of Medical Oncology
    Medical Oncologist Gynecology
    Team Leader, Gynecologic Translational Research Lab, INSERM u981
    Institut Gustave Roussy
    Villejuif, France

    Catherine Fahey, MD, PhD
    Assistant Professor
    Division of Oncology
    University of North Carolina at Chapel Hill
    Chapel Hill, North Carolina

    Link to full program:
    https://bit.ly/42iEDjV

    To claim credit for listening to this episode, please visit the podcast online at the link above.

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