• Genome editing: a lot to think about
    Apr 25 2025

    Tanya Brigden discusses the ethical implications and regulatory challenges that should be considered in the innovative area of genome editing. In recent years, the potential of somatic genome editing has elicited both excitement and caution among researchers, clinicians, patients, and ethicists.

    Welcome back to Making science work for health, the PHG Foundation podcast that explains the most promising developments in science and their implications for healthcare.

    In each episode, host Ofori Canacoo discusses with a PHG Foundation policy analyst, the underpinning science, the ambitions for improving population health and the impact it could have on patients, on society and on the people delivering your healthcare.

    If you would like to find out more about what was discussed in this episode, you can find additional information on our website, phgfoundation.org.

    Make sure to read our briefing on advanced therapy medicinal products as mentioned in the episode.

    If you have any questions about the topic then you can email us at intelligence@phgfoundation.org.

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    25 mins
  • Electrogenetics: another tool for precision medicine?
    Apr 11 2025

    A developing area in synthetic biology, electrogenetics is hoped to become a new avenue in precision medicine, helping with the treatment of certain chronic diseases. Chaitanya Erady talks about what electrogenetics is and the ambitions for its use.

    Welcome back to Making science work for health, the PHG Foundation podcast that explains the most promising developments in science and their implications for healthcare.

    In each episode, host Ofori Canacoo discusses with a PHG Foundation policy analyst, the underpinning science, the ambitions for improving population health and the impact it could have on patients, on society and on the people delivering your healthcare.

    If you would like to find out more about what was discussed in this episode, you can find additional information on our website, phgfoundation.org.

    Make sure to read our briefings on electrogenetics and advanced therapy medicinal products too.

    If you have any questions about the topic then you can email us at intelligence@phgfoundation.org.

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    17 mins
  • A look at gene therapy for type 1 diabetes
    Mar 10 2025

    Type 1 diabetes is a complex disease affecting millions of people across the world. Though insulin has been discovered as a treatment for patients, research is still being done to find additional and alternative methods to treat and perhaps cure type 1 diabetes. Hayley Wilson discusses how gene therapy is being used as one potential method of treatment.

    Welcome back to Making science work for health, the PHG Foundation podcast that explains the most promising developments in science and their implications for healthcare.

    In each episode, host Ofori Canacoo discusses with a PHG Foundation policy analyst, the underpinning science, the ambitions for improving population health and the impact it could have on patients, on society and on the people delivering your healthcare.

    If you would like to find out more about what was discussed in this episode, you can find additional information on our website, phgfoundation.org.

    You can read our briefing on gene therapy and type 1 diabetes here.

    If you have any questions about the topic then you can email us at intelligence@phgfoundation.org.

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    27 mins
  • Digital twins for health care and research
    Dec 12 2024

    Bhavya Krishnan and Dr Elizabeth Redrup Hill discuss the applications of digital twins in the healthcare system, why there is growing interest, and some questions that they would like to see be explored in order to make digital twins an effective tool for healthcare and medicine.

    Welcome back to Making science work for health, the PHG Foundation podcast that explains the most promising developments in science and their implications for healthcare.

    In each episode, host Ofori Canacoo discusses with a PHG Foundation policy analyst, the underpinning science, the ambitions for improving population health and the impact it could have on patients, on society and on the people delivering your healthcare.

    If you would like to find out more about what was discussed in this episode, you can find additional information on our website, phgfoundation.org.

    Regarding digital twins, you can read our explainer about this engineering concept.

    If you have any questions about the topic then you can email us at intelligence@phgfoundation.org.

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    22 mins
  • Phages: a virus on our side?
    Dec 5 2024

    Chantal Babb de Villiers, Senior Policy Analyst at the PHG Foundation, talks us through bacteriophages, otherwise known as phages, their growing interest, their current usage and what might be needed for phage therapy to take the next steps towards public healthcare.

    Welcome back to Making science work for health, the PHG Foundation podcast that explains the most promising developments in science and their implications for healthcare.

    In each episode, host Ofori Canacoo discusses with a PHG Foundation policy analyst, the underpinning science, the ambitions for improving population health and the impact it could have on patients, on society and on the people delivering your healthcare.

    If you would like to find out more about what was discussed in this episode, you can find additional information on our website, phgfoundation.org.

    Regarding phages, Chantal has written a briefing on Phage therapy to treat AMR infections as well as two blogs: Examining whether viruses can combat antimicrobial resistance and Viruses for good – the case for phages.

    If you have any questions about the topic then you can email us at intelligence@phgfoundation.org.

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    18 mins
  • Can long-read sequencing transform genetic diagnoses?
    Sep 8 2023

    Heather Turner, Policy Analyst at the PHG Foundation, explains for you long-read sequencing, its potential applications and how this new technology measures up against traditional short-read sequencing.

    Welcome back to Making science work for health, the PHG Foundation podcast that explains the most promising developments in science and their implications for healthcare.

    In each episode, host Ofori Canacoo discusses with a PHG Foundation policy analyst, the underpinning science, the ambitions for improving population health and the impact it could have on patients, on society and on the people delivering your healthcare.

    If you would like to find out more about what was discussed in this episode, you can find additional information on our website, phgfoundation.org.

    Heather recently wrote two briefings on long-read sequencing. Both are freely available: Clinical long-read sequencing and Long-read sequencing: Clinical applications and implementation.

    If you have any questions about the topic then you can email us at intelligence@phgfoundation.org.

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    18 mins
  • Polygenic scores – one size does not fit all
    Sep 4 2023

    Dr Sowmiya Moorthie, Senior Policy Analyst at the PHG Foundation, explains polygenic scores, their potential - and their limitations – in predicting risk of common diseases.

    Welcome back to Making science work for health, the PHG Foundation podcast that explains the most promising developments in science and their implications for healthcare.

    In each episode, host Ofori Canacoo discusses with a PHG Foundation policy analyst, the underpinning science, the ambitions for improving population health and the impact it could have on patients, on society and on the people delivering your healthcare.

    Lots more about polygenic scores can be found on the PHG Foundation website phgfoundation.org, where you can also read our latest report on the topic Evaluation of polygenic score applications which was authored by Dr Moorthie.

    If you have any questions about the topic then you can email us at intelligence@phgfoundation.org.

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    20 mins
  • Gene editing animals for organ transplants to humans
    Feb 9 2023

    Dr Chantal Babb de Villiers discusses gene editing animals for organ transplants to humans, otherwise known as xenotransplantation.

    Welcome back to Making science work for health, the PHG Foundation podcast that explains the most promising developments in science and their implications for healthcare.

    In each episode, host Ofori Canacoo discusses with a PHG Foundation policy analyst, the underpinning science, the ambitions for improving population health and the impact it could have on patients, on society and on the people delivering your healthcare.

    You can read Chantal's briefing on xenotransplantation here.

    If you would like to find out more about what was discussed in this episode, you can find additional information on our website, phgfoundation.org.

    If you have any further questions about the topic then you can email us at intelligence@phgfoundation.org.

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    20 mins
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