My guest today is Karthee Madasamy, founding managing partner at MFV Partners, a US-based early-stage, deep-tech focused VC firm.

In this episode, Karthee gives us a quick overview of MFV’s $25 million Harper Court Ventures Fund 1, a specialized vehicle bridging academic research and commercial viability for the deep tech startups coming out of the University of Chicago.

He talks about how the fund addresses critical gaps in early-stage ecosystems through “smart funding,” meaning combining capital with hands-on operational support, to translate lab breakthroughs into viable companies.

The model focuses on high-impact sectors where UChicago holds world-class capabilities, including quantum computing, life sciences, energy, and artificial intelligence. Unlike traditional VC, the fund embeds itself in the university's innovation pipeline – collaborating with accelerators, tapping extensive alumni networks, and guiding startups from IP validation to Series A readiness.

Early bets include Flow Medical, which is developing a next-generation catheter-based therapy to treat acute pulmonary embolism,

SimCare AI, which is developing a platform for clinical skills training and evaluation, and Beacon, which is developing technology that eliminates viruses, bacteria, and molds from air and surfaces.

Karthee also briefly discusses potential takeaways and best practices from partnerships such as the Harper Court fund, which are not new in the US, for the India’s emerging deep tech ecosystem.