Join us on the Concentrating on Chromatography podcast as David Oliva interviews Katelynn Perrault Uptmor, PhD about her recent article, "Detangling the Complex Web of GC x GC Method Development to Support New Users." In this insightful conversation, Katelynn explains the basics of comprehensive two-dimensional gas chromatography (GC x GC), its advantages over traditional one-dimensional GC, and shares practical tips for overcoming common challenges faced by new users.Discover how GC x GC vastly increases separation capacity by combining two columns with different stationary phases, allowing for more efficient analysis of complex samples. Katelynn discusses the key steps in method development, including establishing a good one-dimensional separation, using chromatogram modelers to predict peak behavior, and fine-tuning modulator parameters for optimal peak shape and resolution.Learn about choosing the right column combinations for your specific application, understanding the importance of orthogonality between columns, and leveraging resources like literature and expert advice to optimize your setup. Explore real-world applications of GC x GC in fields like forensics, food analysis, environmental science, and petroleum analysis, where this technique is revolutionizing routine analysis.Whether you're a seasoned chromatographer or just starting out, this interview offers valuable insights into the power and accessibility of GC x GC. Katelynn also shares her recent recognition as an Emerging Leader in chromatography and highlights the exciting work of her undergraduate research group. Katelynn is currently Assistant Professor of Chemistry at William and Mary.