• ADPD 2025 Conference Highlights - Part 1

  • Apr 12 2025
  • Length: 51 mins
  • Podcast

ADPD 2025 Conference Highlights - Part 1

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  • This year's AD/PD Conference was held in Vienna, Austria from the 1st to 5th April. In this first of a two-part special we bring you highlights from the first three days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Amanda Heslegrave, Principle Investigator and Co-Lead of fluid biomarker laboratory from the UK Dementia Research Institute at University College London talks with: Dr Loukia Katsouri, Senior Research Fellow at the UCL Gatsby Foundation. Loukia studies the molecular mechanisms of tau propagation in Alzheimer’s disease. She aims to understand how the presence of tau is affecting the spread and the severity of the disease. Dr Anna Mallach, Research Fellow in the UK Dementia Research Institute at Imperial College London. Anna’s work focusses on understanding the role of cellular interactions in contributing to neurodegenerative diseases. Dr Imogen Swift, Research Scientist at Vesper Bio. Imogen is a neuroscience specialist focusing on biomarker and preclinical development in neurodegenerative therapeutics spanning frontotemporal dementia, Alzheimer's Disease. Here are just a few highlights from the discussion: 🧠 1. Can AI spot cognitive decline in mice before humans can? Discover how machine learning is transforming mouse model analysis to predict impairment – and the surprising gender and breeding effects researchers uncovered. 💊 2. Drug repurposing breakthroughs: affordable hope on the horizon? Find out why microglial activity, mitochondrial senescence, and asthma meds could be the future of dementia drug discovery – without starting from scratch. 🧬 3. Parkinson’s redefined – biologically, not clinically A bold proposal to ditch clinical diagnosis in Parkinson’s research in favour of biomarker-based subtyping. Could it revolutionise how trials are run? 🧫 4. Astrocytes take centre stage – and they might be phagocytosing synapses New data shows waves of astroglial activity and potential astro-microglial crosstalk in Parkinson’s disease – with serious implications for how we model disease. 🩸 5. Could a finger prick diagnose dementia? From dried blood spot kits to large-scale remote testing, hear how researchers are racing to make brain biomarker screening as simple as a home test. -- For more information on the event visit: https://www.adpd.kenes.com Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you’ll find a video version of this podcast on our YouTube Channel - https://youtu.be/fOsiGjXvBPA -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://www.twitter.com/demrescommunity https://www.bsky.app/profile/dementiaresearcher.bsky.social https://www.linkedin.com/company/dementia-researcher -- Download our new community app: https://onelink.to/dementiaresearcher
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