Joni, Deb, Eden, and Trina have been best friends since high school, sharing a bond that has seen them through their teenage years and into adulthood. But now time and circumstance are starting to pull them apart as careers, husbands, and babies get in the way. As their yearly vacation becomes less of a priority - at least for three of the women - how can Joni find a way to draw the four of them back together?

Sam and Clementine have a wonderful, albeit, busy life: they have two little girls, Sam has just started a new dream job, and Clementine, a cellist, is busy preparing for the audition of a lifetime. If there’s anything they can count on, it’s each other. Clementine and Erika are each other’s oldest friends. A single look between them can convey an entire conversation. But theirs is a complicated relationship, so when Erika mentions a last minute invitation to a barbecue with her neighbors, Tiffany and Vid, Clementine and Sam don’t hesitate.

When Rosie and Penn and their four boys welcome the newest member of their family, no one is surprised it's another baby boy. At least their large, loving, chaotic family knows what to expect. But Claude is not like his brothers. One day he puts on a dress and refuses to take it off. He wants to bring a purse to kindergarten. He wants hair long enough to sit on. When he grows up, Claude says, he wants to be a girl.

Perfect Mexican daughters do not go away to college. And they do not move out of their parents' house after high school graduation. Perfect Mexican daughters never abandon their family. But Julia is not your perfect Mexican daughter. That was Olga's role. Then a tragic accident on the busiest street in Chicago leaves Olga dead and Julia left behind to reassemble the shattered pieces of her family. And no one seems to acknowledge that Julia is broken, too. Instead, her mother seems to channel her grief into pointing out every possible way Julia has failed.

The handsome son of wealthy parents, Connor has everything anyone could want...except his family's love and affection. Jailed for years after killing his mother's child-molesting boyfriend, Tony is confused about his sexuality. Manic-depressive Vanessa cuts herself. All three stories intertwine in a brutally honest story about pain and resilience.

When Sarah meets Eddie, they connect instantly and fall in love. To Sarah, it seems as though her life has finally begun. And it's mutual: It's as though Eddie has been waiting for her, too. Sarah has never been so certain of anything. So when Eddie leaves for a long-booked vacation and promises to call from the airport, she has no cause to doubt him. But he doesn't call. Sarah's friends tell her to forget about him, but she can't. She knows something's happened - there must be an explanation.

He was tall, at least six feet, with dirty blond hair that hung over his eyes. His T-shirt read Nietzsche Is My Homeboy. So, that was Matt. Who Julie Seagles likes. A lot. But there is also Finn. Who she flat out loves. Complicated? Awkward? Completely. But really, how was this freshly-minted Boston transplant and newbie college freshman supposed to know that she would end up living with the family of an old friend of her mother’s? This was all supposed to be temporary.

Hermione Winters is captain of her cheerleading team, and in tiny Palermo Heights, this doesn't mean what you think it means. At PHHS, the cheerleaders don't cheer for the sports teams; they are the sports team - the pride and joy of a tiny town. The team's summer training camp is Hermione's last and marks the beginning of the end of...she's not sure what. She does know this season could make her a legend. But during a camp party, someone slips something in her drink. And it all goes black.

Henry Page has never been in love. He fancies himself a hopeless romantic, but the slo-mo, heart palpitating, can't-eat-can't-sleep kind of love that he's been hoping for just hasn't been in the cards for him - at least not yet. Instead he's been happy to focus on his grades, on getting into a semi-decent college, and finally becoming editor of his school newspaper. Then Grace Town walks into his first period class on the third Tuesday of senior year, and he knows everything's about to change.

Other than her real name - Mary-Magdalene Feigenbaum - fifteen-year-old Maggie’s problems seem ordinary. She has tiffs with her too-critical mother, a crush on her cute psychologist, and worries that her only friend - fellow outcast Abigail - is morphing into a popular girl, leaving her behind. But Maggie has a few not-so-ordinary problems. A voice in her head is telling her to kill. And not just anyone. Each time the target is a person who has done something terrible to someone Maggie cares for. You know what you have to do, the voice commands.

Childhood friends Patricia Delfine and Laurence Armstead didn't expect to see each other again after parting ways under mysterious circumstances during high school. After all, the development of magical powers and the invention of a two-second time machine could hardly fail to alarm one's peers and families. But now they're both adults, living in the hipster mecca San Francisco, and the planet is falling apart around them.

Every family has a story.... But for the Guinness family a happy ending looks out of reach. Olly and Mae's marriage is crumbling, their teenage daughter Evie is on a mission to self-destruct and their beloved Pops is dying of cancer. Their once strong family unit is slowly falling apart. But Pops has one final gift to offer his beloved family - a ray of hope to cling to. As his life's journey draws to a close, he sends his family on an adventure across Europe in a camper van, guided by his letters, his wisdom and his love.

When everything has been taken from you, what else is there to do but run? So that’s what Annabelle does - she runs from Seattle to Washington, DC, through mountain passes and suburban landscapes, from long lonely roads to college towns. She’s not ready to think about the why yet, just the how - muscles burning, heart pumping, feet pounding the Earth. But no matter how hard she tries, she can’t outrun the tragedy from the past year, or the person - The Taker - that haunts her.

Everything about Jessie is wrong. At least that's what it feels like during her first week of junior year at her new ultra-intimidating prep school in Los Angeles. Just when she's thinking about hightailing it back to Chicago, she gets an email from a person calling themselves Somebody/Nobody (SN for short), offering to help her navigate the wilds of Wood Valley High School. Is it an elaborate hoax? Or can she rely on SN for some much-needed help?

In all her life, Eustacia "Taisy" Cleary has given her heart to only three men: her first love, Ben Ransom; her twin brother, Marcus; and Wilson Cleary - professor, inventor, philanderer, self-made millionaire, brilliant man, breathtaking jerk, her father. Seventeen years ago Wilson ditched his first family for Caroline, a beautiful young sculptor. In all that time, Taisy's family has seen Wilson, Caroline, and their daughter, Willow, only once.