One Thousand White Women is the story of May Dodd and a colorful assembly of pioneer women who travel to the Western prairies in 1875 to intermarry among the Cheyenne Indians.

It's February, 1852, and all around Chicago, Maggie sees postings soliciting "eligible women" to travel to the gold mines of Goosetown. A young seamstress with a small daughter, she has nothing to lose. She joins 43 other women and two pious reverends on the dangerous 2,000-mile journey west. None are prepared for the hardships they face on the trek or for the strengths they didn't know they possessed. Maggie discovers she’s not the only one looking to leave dark secrets behind.

The Overland Trail, 1853: Naomi May never expected to be widowed at 20. Eager to leave her grief behind, she sets off with her family for a life out West. On the trail, she forms an instant connection with John Lowry, a half-Pawnee man straddling two worlds and a stranger in both. But life in a wagon train is fraught with hardship, fear, and death. Even as John and Naomi are drawn to each other, the trials of the journey and their disparate pasts work to keep them apart.

1916. The two-street town of Wallace is not exactly what Ellen Webster had in mind when she accepted a teaching position in Wyoming, but within a year’s time she’s fallen in love—both with the High Plains and with a handsome cowboy named Charlie Bacon. Life is not easy in the flat, brown corner of the state where winter blizzards are unforgiving and the summer heat relentless. But Ellen and Charlie face it all together, their relationship growing stronger with each shared success, and each deeply felt tragedy.

August 18, 1862: On the Sioux reservation in southwestern Minnesota, Indians desperate for food and freedom rise up against whites in the region. Sarah Wakefield, the wife of a physician, is taken captive with her two babies. Their fate falls into the hands of the warrior Ćaske. As war rages, little does she know how entwined their lives will become.

Colorado, 1880. Gracy Brookens has delivered hundreds, maybe thousands of babies in her lifetime. The only midwife in a small mining town tucked in the Tenmile Range, Gracy is a gifted and important resource for the women of her hardscrabble community. For years she has advised expectant mothers through their pregnancies, guided them through the tortures of labor, and then helped them heal.

Early one morning in 1929, Mary Seneca Steele spontaneously packs a suitcase, gathers up her son and daughter, and drives away in her abusive and dissolute husband’s brand-new Auburn Phaeton automobile, leaving her privileged life in Charleston behind. It is the beginning of a journey of enlightenment that leads Mary “Sen” to the mountains and mysteries of Appalachia, where she will learn unexpected family secrets, create a new life for herself and her children, and finally experience love and happiness before tragedy will once again test her.

In the spring of 1885, 17-year-old Jessilyn Harney finds herself orphaned and alone on her family's homestead. Desperate to fend off starvation and predatory neighbors, she cuts off her hair, binds her chest, saddles her beloved mare, and sets off across the mountains to find her outlaw brother Noah and bring him home. A talented sharpshooter herself, Jess' quest lands her in the employ of the territory's violent, capricious governor, whose militia is also hunting Noah - dead or alive.

Wyoming, 1876. For as long as they have lived on the frontier, the Bemis and Webber families have relied on each other. With no other settlers for miles, it is a matter of survival. But when Ernest Bemis finds his wife, Cora, in a compromising situation with their neighbor, he doesn’t think of survival. In one impulsive moment, a man is dead, Ernest is off to prison, and the women left behind are divided by rage and remorse.

In the ruggedness of the beautiful Kentucky mountains, Honey Lovett has always known that the old ways can make a hard life harder. As the daughter of the famed blue-skinned Troublesome Creek packhorse librarian, Honey and her family have been hiding from the law all her life. But when her mother and father are imprisoned, Honey realizes she must fight to stay free, or risk being sent away for good.

When 15-year-old Marigold becomes pregnant amid the Great Depression, she is rejected by her family and forced to fend for herself. And when she loses her baby in the forest, her whole world turns upside down. She’s even more distraught upon discovering she has an inexplicable power that makes her both beautiful and terrifying - and something of a local legend. Meanwhile, migrant workers Vern and Paul discover a violet-eyed baby and take it upon themselves to care for her.

Growing up on their hardscrabble farm in rural Kentucky, 15-year-old Albertina "Bertie" Winslow has learned a lot from her mama, Polly. She knows how to lance a boil, make a pie crust, butcher a pig, and tend to every chore that needs doing. What she doesn't know, but is forced to reckon with all too soon, is how to look after children as a mother should. When Polly succumbs to a long illness, Bertie takes on responsibility for her four younger siblings and their dissolute, unreliable daddy.

Colorado, 1918. World War I is raging overseas, but it’s the home front battling for survival. With the Spanish Flu rampant, Denver’s schools are converted into hospitals, churches and funeral homes are closed, and nightly horse-drawn wagons collect corpses left in the street. Sisters Helen and Lutie have moved to Denver from Ohio after their parents’ death. Helen, a nurse, and Lutie, a carefree advertising designer at Neusteter’s department store, share a small, neat house and each finds a local beau—for Helen a doctor, for Lutie a young student who soon enlists.

No one is more surprised than Mattie Spenser herself when Luke Spenser, considered the great catch of their small Iowa town, asks her to marry him. Less than a month later, they are off in a covered wagon to build a home on the Colorado frontier. Mattie's only company is a slightly mysterious husband and her private journal, where she records the joys and frustrations not just of frontier life, but also of a new marriage to a handsome, but distant stranger.

Del Wensley, wife of the most celebrated preacher in Harlan County, tries to mind her place. Until her husband’s infidelity pushes an already strained marriage to a breaking point. Clinging to her last hope for self-respect, Del turns her back on the rigid life she’s known. A coal train is rolling through the valley. With her eyes wide open to the unfamiliar, and to the freedom she craves, Del takes to the rails.