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I thought I already knew a lot about this field, but this book provided more

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For the beginner to intermediate to advanced.

For the beginner to intermediate to advanced.
the keys to longevity better Health better Fitness

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The best evidence for a great diet that I've ever

This is a great book on the science behind longevity diets, although it is a bit overcomplicated for simple dietary advice (there's a chapter at the end which is sufficient if you accept what the author says and develops with support, but that chapter should be even more explicitly how-to).

Essentially, based on research about people who have lived past 105 years, blue zones of extreme longevity globally, and laboratory research, it seems that the ideal diet is low-GI plants, with relatively small amounts of high-omega3 fats, and relatively low amounts of protein, with very low carbohydrates generally, particularly high-GI refined carbohydrates. So, essentially the opposite of the mainstream modern diet, but largely in-line with current best dietary advice from most sources.

The somewhat novel part here is having distinct anabolic and catabolic diets throughout the year (roughly 4:8 ratio), and a focus on encouraging autophagy through diet during 8 months of the year to reduce risk of cancer, especially from middle age onward.

The actual advice isn't particularly novel, but the justification and evidence for the advice is better than I've seen before.

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So grateful to have listened to this.

Wow! So insightful, and understandable, even for a high school C student like me. I paced the floor while I listened to it...I was so into it. I’m going to listen to it again immediately. James Clement did us all a huge favor for writing/ sharing this. Thank you for doing the audio version also, as I would have never read, or understood it, like I did. Thanks for caring James.

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Vital Information

So much necessary content! A must read! I have already recommended this book to multiple people. Just finished my second time through the book.

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Eye-Opening!

Enjoyed this read, I can even say it's life changing.

Thank you so much!

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Real Scientist Explains Eating for Healthy Aging

James Clement is a scientist's scientist.
You know, like a musician's musician, as in when your favorite famous musician is asked in an interview who is really great in music and he or she points at someone you've never heard of and says "this person is a truly great musician". A musician's musician. In a similar way we have a scientist's scientist who in this case is the talented, intelligent James Clement diligently working behind the scene in the science of human aging. James has his own non-profit human aging science lab. You might have heard of his work 10 or so years ago when he went around the world collecting DNA samples from the oldest lived humans - the supercentenarian project - done in partnership with Harvard's famously prolific leading light: geneticist George Church. George wrote the forward for this book. Also respected aging research scientist David Sinclair has glowingly reviewed this book. Why? In recent years there have been remarkable scientific advances in understanding mTOR the control center of Anabolism (building protiens) and Catabolism (tearing down, recycling protiens) in essentially all of the 30 trillion or so cells that make up your body.
In the light of this new scientific knowledge, in this book James Clement explains in simple clear language, how: when and what you eat can dramatically improve your health and wellbeing.
Get this book! It's great!

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Don’t let the numbers overpower the story

James Clement does a wonderful job of mixing biology with story to build a strong case for the positive health influences of intermittent fasting and ketogenic eating.

Michael Axtell’s narration kept me listening even during the citing of long website URL’s. Thank you Michael.

I would encourage listeners and readers to hang on until the end using the building blocks of biology to build the desire to use food as medicine.

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Very selective about any science presented.

Stating meat has similar metabolic response as sugar concerning insulin resistance. Hello? Ancient religious practices from various groups, cults , etc . No thanks . Hard science , hardly.

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TVP over grass-fed lamb? Really?

So, while I really like the mTOR/autophagy cycling, and plan to include that in my own routine, James has a plant based leaning that I find just a bit irritating. While there is very little question that we need to get a lot of low glycemic vegetables in our diets, his suggestion that we get so very little animal protein and include such things as TVP are almost shocking. And, his claim that we need to severely limit animal based saturated fats, which he calls "bad" fats and try for really low LDL, which he calls "bad" cholesterol is so yesterday. I mean, he suggests limiting pastured eggs to two per week and limiting meat to once a week! He even points out the big difference in the lipid profile of grass-fed ruminants vs grain finished ruminants, but then still says we should not eat much grass-fed beef or lamb. He likes keto, and points out that we might want to avoid seed oils because of their poor omega 3 to omega 6 ratio, among other reasons, but then says avoid animal source saturated fat. Hmm, I guess I will be drinking me some olive oil... The idea that all LDL is "bad" cholesterol is most definitely in question these days. What kind of LDL (fluffy or dense)? How did it get low? Clement even points out that, in an Australian study, the group that switched to vegetable oil PUFAs to lower LDL died from so many more heart attacks than the Mediterranean diet group that they terminated the study! Plus, recent data shows that, for those of us over 60, higher LDL seems to be correlated with lower all cause mortality. This book is worth reading, if just for the mTOR cycling idea, but I find it to be a little weak on some of the nutritional suggestions.

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34 people found this helpful