The plague raging through London in 1665 has emptied the city. The only people left are those too poor to flee or those who selflessly struggle to control the contagion and safeguard the capital's future. Amongst them, though, are those prepared to risk their health for money - those who sell dubious 'cures' and hawk food at wildly inflated prices. Also amongst them are those who hold in their hands the future of the city's most iconic building - St Paul's Cathedral.

In the sapping summer heat of 1665, there is little celebration in London of the naval victory at the Battle of Lowestoft. The King, his retinue and anyone with sufficient means has fled the plague-ridden city, its half-deserted streets echoing the sound of bells tolling the mounting number of deaths. Those who remain clutch doubtful potions to ward off the relentless disease and dart nervously past shuttered buildings, watchful for the thieves who risk their lives to plunder what has been left behind.

Matthew Bartholomew, unorthodox but effective physician to Michaelhouse college in medieval Cambridge, is as worried as anyone about the pestilence that is ravaging Europe and seems to be approaching England. But he is distracted by the sudden and inexplicable death of the Master of Michaelhouse - a death the University authorities do not want investigated.

Hugh of Singleton, fourth son of a minor knight, has been educated as a clerk, usually a prelude to taking holy orders. However, feeling no certain calling despite a lively faith, he turns to the profession of surgeon, training in Paris and then hanging out his sign in Oxford. A local lord asks him to track the killer of a young woman whose bones have been found in the castle cesspit. She is identified as the impetuous missing daughter of a local blacksmith, and her young man, whom she had provoked very publicly, is in due course arrested and sentenced at the Oxford assizes.

His name was Will Fowler, an actor in the esteemed theatrical company called Lord Westfield’s Men, a vibrant young man flushed from the success of a recent performance at the Queen’s Head theatre. So exuberant was he that he persuaded the resourceful manager of the company, Nicholas Bracewell, to quaff a pint or two at a nearby pub.

The much-feared and hated Eudo - the Lord Bishop of Winchester's clerk - is bludgeoned to death in Pershore Abbey and laid before the altar in the attitude of a penitent. Everyone who had contact with him had reason to dislike him, but who had reason to kill him? The Sheriff of Worcestershire's thief taker, wily Serjeant Catchpoll, and his new and unwanted superior, Undersheriff Hugh Bradecote, have to find the answer. And as the walls of the abbey close in on the suspects, the killer strikes again....

London, September 1666. The Great Fire rages through the city, consuming everything in its path. Even the impregnable cathedral of St. Paul's is engulfed in flames and reduced to ruins. Among the crowds watching its destruction is James Marwood, son of a disgraced printer and reluctant government informer. In the aftermath of the fire, a semi-mummified body is discovered in the ashes of St. Paul's, in a tomb that should have been empty. The man's body has been mutilated, and his thumbs have been tied behind his back.

Salisbury, 1226. A young pregnant woman is found tangled in reeds in the river Avon, her identity a mystery. Grieving widow Ela Longespée is determined to succeed her husband as sheriff of Salisbury, and quickly takes charge of the investigation. She soon finds herself in the thick of a neighborhood scandal and a struggle to maintain her authority. With multiple suspects, can she identify the true killer?

Ralph Delchard, a soldier who fought at the Battle of Hastings, and Gervase Bret, a talented lawyer, have been commissioned by William the Conqueror to look into irregularities brought to light during the compilation of the Domesday Book. A man’s body is found mutilated in Savernake Forest and the residents of Bedwyn sleep uneasy at night, fearing a monster stalking the town. When Ralph Delchard and Gervase Bret arrive, they discover that the locals are harbouring dark secrets and that the real killer may be a little closer to home....

Lady Emily Hardcastle is an eccentric widow with a secret past. Florence Armstrong, her maid and confidante, is an expert in martial arts. The year is 1908 and they've just moved from London to the country, hoping for a quiet life. But it is not long before Lady Hardcastle is forced out of her self-imposed retirement. There's a dead body in the woods, and the police are on the wrong scent. Lady Hardcastle makes some enquiries of her own, and it seems she knows a surprising amount about crime investigation...

Spring, 1918. The Great War is at a crucial stage, the Germans are making one last push into France, and the Allies are struggling to hold them back. Battle lines are shifting, and men, and their machines, are being sent up and down the front to shore up defenses. Major Heathcliff Lennox, and his batman Greggs, are told to report to their new HQ. They set off on a sunlit day to fly the distance, but the enemy is never far away, and disaster strikes. They're sent crashing to the ground behind enemy lines, where life, death, and love await.

England, 1925. After years shut away from the world, former detective Lord Edgington of Cranley Hall plans a grand ball to celebrate his seventy-fifth birthday. But when someone starts bumping off members of his scheming family, the old man enlists his teenage grandson to help find the killer, before one of them is next.

At the end of his Grand Tour, somewhere between Athens and Constantinople, Christian Selwyn, the young Earl of Hazelmere, vanished—seemingly without trace. Time passes. In London, his uncle and cousin move into his home, while his unofficial fiancée, Sophia, is left desolate and in limbo.

The daughter of a baronet and minor heiress, Rosalind Thorne was nearly ruined after her father abandoned the family. To survive in the only world she knew, she began to manage the affairs of some of London society's most influential women, who rely on her wit and discretion. So when artistocratic wastrel Jasper Aimesworth is found dead in London's most exclusive ballroom, Almack's, Rosalind must use her skills and connections to uncover the killer.

London, 1861. Samantha Kingston has lived under the control of her overbearing uncle since the death of her parents six years ago. Trapped by the conventions of her gender and social class, she is desperate to find a way out. But when her aunt and uncle are murdered, the freedom she sought seems even further out of reach. A suspect in the crime, she finds herself on the run, unsure whom to trust, lost in the underworld she had only ever read about in the pages of a Dickens novel.