London, 1923. Newly minted research assistant Saffron Everleigh is the first woman to hold the position at University College of London. When she attends a dinner party for the school, she expects to engage in conversations about the university's large expedition to the Amazon. What she doesn’t expect is for Mrs. Henry, one of the professors’ wives, to drop to the floor, poisoned by an unknown toxin. Dr. Maxwell, Saffron’s mentor, is the main suspect, and evidence quickly mounts.

High school senior Andrew Perrault finds refuge in the twisted fairy tales that he writes for the only person who can ground him to reality—Thomas Rye, the boy with perpetually ink-stained hands and hair like autumn leaves. And with his twin sister, Dove, inexplicably keeping him at a cold distance upon their return to Wickwood Academy, Andrew finds himself leaning on his friend even more. But something strange is going on with Thomas. His abusive parents have mysteriously vanished, and he arrives at school with blood on his sleeve.

Jocasta is just fifteen when she is told that she must marry the King of Thebes, an old man she has never met. Her life has never been her own, and nor will it be, unless she outlives her strange, absent husband. Ismene is the same age when she is attacked in the palace she calls home. Since the day of her parents' tragic deaths a decade earlier, she has always longed to feel safe with the family she still has. But with a single act of violence, all that is about to change. With the turn of these two events, a tragedy is set in motion. But not as we’ve known it.

When Princess Atalanta is born, a daughter rather than the son her parents hoped for, she is left on a mountainside to die. But even then, she is a survivor. Raised by a mother bear under the protective eye of the goddess Artemis, Atalanta grows up wild and free, with just one condition: if she marries, Artemis warns, it will be her undoing. Although she loves her beautiful forest home, Atalanta yearns for adventure. When Artemis offers her the chance to fight in her name alongside the Argonauts, the fiercest band of warriors the world has ever seen, Atalanta seizes it.

Before Gods and mortals, there were The Fates - three sisters born out of Nyx's darkness, destined to weave the lives, and deaths, of humankind for eternity. But immortality is a heavy burden, and Clotho, Lachesis and Atropos are captivated by the gloriously human lives of the mortals below, especially those of the great warrior Atalanta and her ill-fated lover, Meleager. However, being a Goddess of Fate doesn't make you a master of it. Will these three sisters find a way to free the couple, and themselves, from their destinies? Or will they be bound by Fate forever?