It is May 1706. Ana, a young Spanish woman, lives in a small town on the north-west coast of Tenerife with her mother and twin younger brothers. The town is in the shadow of a mighty volcano, which legend says has the devil living inside it. However, there has been no eruption for thousands of years, and no one believes it is a threat. One day, Ana notices that the air feels strange and heavy, that the birds have stopped singing. Tending the family vineyard, a sudden strange tremor in the earth frightens her.

In the winter of 1928, still seeking some kind of resolution to the horrors of World War I, Freddie is traveling through the beautiful but forbidding French Pyrenees. During a snowstorm, his car spins off the mountain road. Dazed, he stumbles through the woods, emerging in a tiny village, where he finds an inn to wait out the blizzard. There he meets Fabrissa, a lovely young woman also mourning a lost generation.

Heir to a fortune, Marguerite is destined for a life of prosperity and gentility. Then she is orphaned, and her guardian—an enigmatic and volatile man—spends her inheritance and insists she accompany him on an expedition to New France. That journey takes a unexpected turn when Marguerite, accused of betrayal, is brutally punished and abandoned on a small island.

In the ancient city of Nineveh, on the bank of the River Tigris, King Ashurbanipal of Mesopotamia, erudite but ruthless, built a great library that would crumble with the end of his reign. From its ruins, however, emerged a poem, the Epic of Gilgamesh, that would infuse the existence of two rivers and bind together three lives. In 1840 London, Arthur is born beside the stinking, sewage-filled River Thames. With an abusive, alcoholic father and a mentally ill mother, Arthur’s only chance of escaping destitution is his brilliant memory.

In a bid to outrun her past, Carrie Ballentyne accepts a nursing position with a doctor in the New Mexico Territory. She knows the journey from New York to Santa Fe will not be easy, but she relishes the adventure. However, nothing could have prepared her for the wilderness she encounters. Its vastness and power are awe-inspiring, stunning in both beauty and brutality. To endure, she must learn to rely on her fellow travelers—and one enigmatic man in particular. As the small, tight-knit group tackles challenge after challenge, she feels her heart opening to this rugged land.

In July 2005, in the Pyrenees mountains near Carcassonne, Alice, a volunteer at an archaeological dig, stumbles into a cave and makes a startling discovery-two crumbling skeletons, strange writings on the walls, and the pattern of a labyrinth.

In a remote village near the English coast, residents gather in a misty churchyard. More than a decade into the 20th century, superstition still holds sway: It is St. Mark's Eve, the night when the shimmering ghosts of those fated to die in the coming year are said to materialize and amble through the church doors. Alone in the crowd is Constantia Gifford, the taxidermist's daughter. Twenty-two and unmarried, she lives with her father on the fringes of town, in a decaying mansion.

The Salpêtrière Asylum: Paris, 1885. Genevieve is a senior nurse. After the childhood death of her sister, Blandine, she shunned religion and placed her faith in both the celebrated psychiatrist Dr. Charcot and science. But everything begins to change when she meets Eugénie, the 19-year-old daughter of a bourgeois family that has locked her away in the asylum. Because Eugénie has a secret: She sees spirits.

In the winter of 1928, still seeking some kind of resolution to the horrors of World War I, Freddie is traveling through the beautiful but forbidding French Pyrenees. During a snowstorm, his car spins off the mountain road. Dazed, he stumbles through the woods, emerging in a tiny village, where he finds an inn to wait out the blizzard. There he meets Fabrissa, a lovely young woman also mourning a lost generation.

Thirty-eight year old Cassandra is lost, alone, and grieving. Her much loved grandmother, Nell, has just died and Cassandra, her life already shaken by a tragic accident 10 years ago, feels like she has lost everything known and dear to her.