Liverpool, 1868. Shrouded in secrecy, Alice Sampson gives birth to a beautiful baby girl. But the former nurse's happiness is blighted by the knowledge that as a penniless, unwed mother, her future, and that of her child, can only be one of shame and disgrace. Then a knock at the door brings a miracle: she is invited to return to the Liverpool Royal Infirmary and her beloved ward. With the help of her friends and the welcome attentions of Reverend Seed, the hospital Chaplain, Alice slowly starts to rebuild her life.

England, 1941. After three nights of relentless bombing from German aircraft, trained nurse Jo Brooks is told to report to the basement theater of Mill Road Hospital. She goes with a heavy heart, not wanting to leave behind her best friend Moira, who is desperately soothing new mothers on the maternity ward. As Jo arrives safely underground, the ward takes a direct hit.

1918, London. Twenty-year-old Emily Burdon has been training as a nurse at St. Marylebone Infirmary, learning on the job as she tends to patients from the crowded poorhouses that ring the hospital as well as wounded soldiers returning from the war. She pours her heart into her nursing while she waits for happier times - peace in Europe and the return of her childhood sweetheart, Lewis, from the Western Front. But when the deadly Spanish Flu arrives in London on the heels of the war, Emily’s faith and courage are put to the test.

Daisy Wilder prefers the company of horses to people, bare feet and salt water to high heels and society parties. Then, in the dizzying aftermath of the attack on Pearl Harbor, Daisy enlists in a top secret program, replacing male soldiers in a war zone for the first time. Under fear of imminent invasion, the WARDs guide pilots into blacked-out airstrips and track unidentified planes across Pacific skies. But not everyone thinks the women are up to the job, and the new recruits must rise above and work side by side despite the resistance and heartache they meet along the way.

On Memorial Day in Jewel, Minnesota, the body of wealthy landowner Jimmy Quinn is found floating in the Alabaster River, dead from a shotgun blast. The investigation falls to Sheriff Brody Dern, a highly decorated war hero who still carries the physical and emotional scars from his military service. Even before Dern has the results of the autopsy, vicious rumors begin to circulate that the killer must be Noah Bluestone, a Native American WWII veteran who has recently returned to Jewel with a Japanese wife.

Liverpool, 1939. Bella Rogers thought her life was just starting; she can’t wait to get married to her childhood sweetheart, Bobby. But when war is declared and Bobby is called up, his letters stop, leaving Bella heartbroken and alone. Then her family is torn apart by tragedy when her angelic 5-year-old sister dies from a terrible illness. They can barely afford a funeral, but the church is packed with the entire community, devastated for their loss. Grieving for her sister and lost love, Bella finds a job at the Bryant and May factory, making matches.

Occupied France, 1940. When the staff at a field hospital draw straws to find out who will join the evacuation from Dunkirk, Nurse Cate is left behind. But when the Nazis arrive to claim prisoners of war, she takes her chance and flees into the night, taking one patient with her. Fifty miles away, the surrendering soldiers of the Royal Norfolk Regiment are shot dead by the advancing Germans. Beneath the pile of bodies two men survive, crawling to the safety of a nearby farmhouse, where sisters Elise and Adelaide risk their lives to take them in.

As the German Luftwaffe begin a terrifying bombing campaign that will come to be known as the Blitz, thousands are evacuated to safety. But Lizzie Mackenzie finds herself heading toward London. She knows she must help in the war effort. But she has another reason for leaving the security of her Scottish village: the illegitimate child she gave up for adoption nearly five years before is somewhere in the city. And - as the bombs rain down - she will stop at nothing to find her and make sure her little girl is safe.

London 1940. As the war rages in Europe, Rose Brown steps on board a ship bound for America, hoping to escape the danger. She's frightened, but her widowed mammy and three sisters in Ireland need the money she earns as nanny to the rich Townsend family. But while Rose plays with baby Sarah in the salty spray on deck, disaster strikes, and the ocean liner begins to sink. In the chaos, Rose and the baby are separated from the family.

Marion and Shiva Stone are twin brothers born of a secret union between a beautiful Indian nun and a brash British surgeon. Orphaned by their mother’s death and their father’s disappearance, bound together by a preternatural connection and a shared fascination with medicine, the twins come of age as Ethiopia hovers on the brink of revolution.

How far would you go to protect your family? Single dad Ben is doing his best to raise his children, with the help of his devoted mother, Judi. And then Ben meets Amber. Everyone thinks this is a perfect match for Ben, but Judi isn't so sure.... There's just something about Amber that doesn't add up. Ben can't see why his mother dislikes his new girlfriend. And Amber doesn't want Judi anywhere near her new family. Amber just wants Ben and the children.

West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.

Barry Laverty, M.B., can barely find the village of Ballybucklebo on a map when he first sets out to seek gainful employment there, but already he knows that there is nowhere he would rather live than in the emerald hills and dales of Northern Ireland. The proud owner of a spanking-new medical degree and little else in the way of worldly possessions, Barry jumps at the chance to secure a position as an assistant in a small rural practice. At least until he meets Dr. Fingal Flahertie O'Reilly.

Welcome to the district nurses' home on Steeple Street, where everyone has a secret.... Ambitious young nurse Agnes Sheridan had a promising future ahead of her until a tragic mistake cost her the love and respect of everyone around her. Now she has come to Leeds for a fresh start as a trainee district nurse. But Agnes finds herself facing unexpected challenges as she is assigned to Quarry Hill, one of the city's most notorious slums.

When Cissy Ryan’s real mother comes to claim her from the workhouse, it’s not how she imagined. Her family’s tumbledown cottage has ice on the inside of its windows and is in an isolated, poverty-stricken village in the muddy Irish countryside. But when Cissy is allowed to help neighbour Colm Doyle and his horse named Blue on their milk round one morning, Cissy starts to feel as though friendship could get her through anything.