
The Invisible Siege
The Rise of Coronaviruses and the Search for a Cure
Failed to add items
Add to Cart failed.
Add to Wish List failed.
Remove from wishlist failed.
Adding to library failed
Follow podcast failed
Unfollow podcast failed
$0.99/mo for the first 3 months

Buy for $20.25
No default payment method selected.
We are sorry. We are not allowed to sell this product with the selected payment method
-
Narrated by:
-
Jason Culp
-
By:
-
Dan Werb
About this listen
“A journey into the origins of COVID-19 and the discovery of vaccines and potential cures . . . I learned so much that I didn’t know before—above all, I met the subtle warriors of the laboratory who are working to save all of us from the horror of new pandemics.”—Richard Preston, bestselling author of The Hot Zone and The Demon in the Freezer
Winner of the Hilary Weston Writers’ Trust Prize • One of Publishers Weekly’s top ten science books of the season
The urgency of the devastating COVID-19 pandemic has fixed humanity’s gaze on the present crisis. But the story of this pandemic extends far further back than many realize. In this engrossing narrative, epidemiologist Dan Werb traces the rising threat of the coronavirus family and the attempts by a small group of scientists who worked for decades to stop a looming viral pandemic.
When virologist Ralph Baric began researching coronaviruses in the 1980s, the field was a scientific backwater—the few variants that infected humans caused little more than the common cold. But when a novel coronavirus sparked the 2003 SARS epidemic, and then the MERS epidemic a decade later, Baric and his allies realized that time was running out before a pandemic strain would make the inevitable jump from animals to human hosts.
In The Invisible Siege, Werb unpacks the dynamic history and microscopic complexity of an organism that has wreaked cycles of havoc upon the world for millennia. Elegantly tracing decades of scientific investigation, Werb’s book reveals how Baric’s team of scientists hatched an audacious plan not merely to battle COVID-19 but to end pandemics forever. Yet as they raced to find a cure, they ran into a complicated nexus of science, ethics, industry, and politics that threatened to derail their efforts just as COVID-19 loomed ever larger.\
The Invisible Siege is an urgent and moving testament to the unprecedented scientific movement to stop COVID-19—and a powerful look at the infuriating factors that threaten to derail discovery and leave the world vulnerable to the inevitable coronaviruses to come.
©2022 Dan Werb (P)2022 Random House AudioListeners also enjoyed...
-
Viral
- The Search for the Origin of COVID-19
- By: Matt Ridley, Alina Chan
- Narrated by: Gavin Osborn
- Length: 11 hrs and 16 mins
- Unabridged
-
Overall
-
Performance
-
Story
A new virus descended on the human species in 2019 wreaking unprecedented havoc. Nearly two years into the pandemic, the crucial mystery of the origin of SARS-CoV-2 is not only unresolved but has deepened. In this uniquely insightful book, a scientist and a writer join forces to try to get to the bottom of how a virus whose closest relations live in bats in subtropical southern China somehow managed to begin spreading among people more than 1,500 kilometers away in the city of Wuhan.
-
-
A pivotal work in search of truth around the Covid19 virus in a world where facts got downgraded in favour of politics
- By Pal on 11-25-21
By: Matt Ridley, and others
-
The Code Breaker
- Jennifer Doudna, Gene Editing, and the Future of the Human Race
- By: Walter Isaacson
- Narrated by: Kathe Mazur, Walter Isaacson
- Length: 16 hrs and 4 mins
- Unabridged
-
Overall
-
Performance
-
Story
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
-
-
Except for the author, this book is good!
- By Johan on 03-14-21
By: Walter Isaacson
-
The Song of the Cell
- An Exploration of Medicine and the New Human
- By: Siddhartha Mukherjee
- Narrated by: Dennis Boutsikaris
- Length: 16 hrs and 3 mins
- Unabridged
-
Overall
-
Performance
-
Story
From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.
-
-
Beyond Words Wonderful
- By Lynn on 11-27-22
-
Immune
- A Journey into the Mysterious System That Keeps You Alive
- By: Philipp Dettmer
- Narrated by: Steve Taylor
- Length: 10 hrs and 28 mins
- Unabridged
-
Overall
-
Performance
-
Story
You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. So what, exactly, is your immune system? In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes listeners on a journey through the fortress of the human body and its defenses.
-
-
Steve Taylor for the win
- By Bay Area Engineer on 11-02-21
By: Philipp Dettmer
-
Blowback
- A Warning to Save Democracy from the Next Trump
- By: Miles Taylor
- Narrated by: Miles Taylor
- Length: 12 hrs and 57 mins
- Unabridged
-
Overall
-
Performance
-
Story
Donald Trump will be president again, whether he is on the ballot or not. That is because Trumpism is overtaking the Republican Party and will mount a vigorous comeback, potentially in the hands of a savvier successor. This prophecy will come true, according to Miles Taylor, if we do not learn the lessons of the recent past. With the 2024 election approaching, the formerly “Anonymous” official is back with bombshell revelations and a sobering national forecast. Taylor predicts what could happen inside “Trump 2.0,” the White House of a more competent and more formidable copycat.
-
-
We will only have ourselves to blame if we sink into autocracy
- By MS on 07-23-23
By: Miles Taylor
-
Breathless
- The Scientific Race to Defeat a Deadly Virus
- By: David Quammen
- Narrated by: Jacques Roy
- Length: 13 hrs and 26 mins
- Unabridged
-
Overall
-
Performance
-
Story
Breathless is story of SARs-CoV-2 and its fierce journey through the human population, as seen by the scientists who study its origin, its ever-changing nature, and its capacity to kill us. David Quammen expertly shows how strange new viruses emerge from animals into humans as we disrupt wild ecosystems and how those viruses adapt to their human hosts, sometimes causing global catastrophe. He explains why this coronavirus will probably be a “forever virus,” destined to circulate among humans and bedevil us endlessly, in one variant form or another.
-
-
Loved it!
- By Melissa on 03-10-23
By: David Quammen
-
Viral
- The Search for the Origin of COVID-19
- By: Matt Ridley, Alina Chan
- Narrated by: Gavin Osborn
- Length: 11 hrs and 16 mins
- Unabridged
-
Overall
-
Performance
-
Story
A new virus descended on the human species in 2019 wreaking unprecedented havoc. Nearly two years into the pandemic, the crucial mystery of the origin of SARS-CoV-2 is not only unresolved but has deepened. In this uniquely insightful book, a scientist and a writer join forces to try to get to the bottom of how a virus whose closest relations live in bats in subtropical southern China somehow managed to begin spreading among people more than 1,500 kilometers away in the city of Wuhan.
-
-
A pivotal work in search of truth around the Covid19 virus in a world where facts got downgraded in favour of politics
- By Pal on 11-25-21
By: Matt Ridley, and others
-
The Code Breaker
- Jennifer Doudna, Gene Editing, and the Future of the Human Race
- By: Walter Isaacson
- Narrated by: Kathe Mazur, Walter Isaacson
- Length: 16 hrs and 4 mins
- Unabridged
-
Overall
-
Performance
-
Story
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
-
-
Except for the author, this book is good!
- By Johan on 03-14-21
By: Walter Isaacson
-
The Song of the Cell
- An Exploration of Medicine and the New Human
- By: Siddhartha Mukherjee
- Narrated by: Dennis Boutsikaris
- Length: 16 hrs and 3 mins
- Unabridged
-
Overall
-
Performance
-
Story
From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.
-
-
Beyond Words Wonderful
- By Lynn on 11-27-22
-
Immune
- A Journey into the Mysterious System That Keeps You Alive
- By: Philipp Dettmer
- Narrated by: Steve Taylor
- Length: 10 hrs and 28 mins
- Unabridged
-
Overall
-
Performance
-
Story
You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. So what, exactly, is your immune system? In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes listeners on a journey through the fortress of the human body and its defenses.
-
-
Steve Taylor for the win
- By Bay Area Engineer on 11-02-21
By: Philipp Dettmer
-
Blowback
- A Warning to Save Democracy from the Next Trump
- By: Miles Taylor
- Narrated by: Miles Taylor
- Length: 12 hrs and 57 mins
- Unabridged
-
Overall
-
Performance
-
Story
Donald Trump will be president again, whether he is on the ballot or not. That is because Trumpism is overtaking the Republican Party and will mount a vigorous comeback, potentially in the hands of a savvier successor. This prophecy will come true, according to Miles Taylor, if we do not learn the lessons of the recent past. With the 2024 election approaching, the formerly “Anonymous” official is back with bombshell revelations and a sobering national forecast. Taylor predicts what could happen inside “Trump 2.0,” the White House of a more competent and more formidable copycat.
-
-
We will only have ourselves to blame if we sink into autocracy
- By MS on 07-23-23
By: Miles Taylor
-
Breathless
- The Scientific Race to Defeat a Deadly Virus
- By: David Quammen
- Narrated by: Jacques Roy
- Length: 13 hrs and 26 mins
- Unabridged
-
Overall
-
Performance
-
Story
Breathless is story of SARs-CoV-2 and its fierce journey through the human population, as seen by the scientists who study its origin, its ever-changing nature, and its capacity to kill us. David Quammen expertly shows how strange new viruses emerge from animals into humans as we disrupt wild ecosystems and how those viruses adapt to their human hosts, sometimes causing global catastrophe. He explains why this coronavirus will probably be a “forever virus,” destined to circulate among humans and bedevil us endlessly, in one variant form or another.
-
-
Loved it!
- By Melissa on 03-10-23
By: David Quammen
-
The Great Influenza
- The Epic Story of the Deadliest Plague in History
- By: John M. Barry
- Narrated by: Scott Brick
- Length: 19 hrs and 26 mins
- Unabridged
-
Overall
-
Performance
-
Story
In the winter of 1918, at the height of World War I, history's most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in 24 weeks than AIDS has killed in 24 years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision between modern science and epidemic disease.
-
-
Great book but very disturbing...
- By Tim on 01-15-09
By: John M. Barry
-
Firmament
- The Hidden Science of Weather, Climate Change and the Air That Surrounds Us
- By: Simon Clark
- Narrated by: Simon Clark
- Length: 5 hrs and 59 mins
- Unabridged
-
Overall
-
Performance
-
Story
In Firmament, atmospheric scientist and science communicator Simon Clark offers a rare and accessible tour of the ins and outs of the atmosphere and how we know what we know about it. From the workings of its different layers to why carbon dioxide is special, from pioneers like Pascal to the unsung heroes working in the field to help us understand climate change, Firmament introduces us to an oft-overlooked area of science and not only lays the ground work for us to better understand the debates surrounding the climate today.
-
-
The Beauty & importance of atmospheric science
- By Jacob Brenner on 08-02-24
By: Simon Clark
-
Food: A Cultural Culinary History
- By: Ken Albala, The Great Courses
- Narrated by: Ken Albala
- Length: 18 hrs and 22 mins
- Original Recording
-
Overall
-
Performance
-
Story
Eating is an indispensable human activity. As a result, whether we realize it or not, the drive to obtain food has been a major catalyst across all of history, from prehistoric times to the present. Epicure Jean-Anthelme Brillat-Savarin said it best: "Gastronomy governs the whole life of man."
-
-
One of my top 3 favorite courses!
- By Jessica on 12-28-13
By: Ken Albala, and others
-
Warp Speed
- Inside the Operation That Beat COVID, the Critics, and the Odds
- By: Paul Mango
- Narrated by: Chris Abell
- Length: 5 hrs and 6 mins
- Unabridged
-
Overall
-
Performance
-
Story
The prior record for vaccine development and distribution was approximately four-and-a-half years. Operation Warp Speed got the COVID-19 vaccine to the American people in less than ten months. Operation Warp Speed did not happen by accident. It was the result of exceptional leadership, explicit strategy, and unprecedented teamwork. Author Paul Mango, one of the key leaders of Operation Warp Speed and the former deputy chief of US Health and Human Services, chronicles the challenges of developing the vaccine.
-
-
Extremely political
- By Vicki D. Jackman on 11-20-23
By: Paul Mango
-
Pandemia
- How Coronavirus Hysteria Took Over Our Government, Rights, and Lives
- By: Alex Berenson
- Narrated by: Alex Berenson
- Length: 11 hrs and 1 min
- Unabridged
-
Overall
-
Performance
-
Story
The most important fact about the coronavirus pandemic that turned the world upside down in 2020 is that our response to it has been an epic overreaction driven by a disastrous confluence of public and private interests - all of them purporting to “follow the science”. Since the lockdowns began, millions of Americans have relied on the reporting of Alex Berenson. Exposing the hysteria and manipulation behind the worst failure of public policy since World War I, this clear-eyed journalist has been a critical source of reason and truth.
-
-
Outstanding
- By Robert M on 11-30-21
By: Alex Berenson
-
The Emperor of All Maladies
- A Biography of Cancer
- By: Siddhartha Mukherjee
- Narrated by: Fred Sanders
- Length: 22 hrs and 18 mins
- Unabridged
-
Overall
-
Performance
-
Story
The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
-
-
Incredible
- By S.R.E. on 03-02-16
-
Deadliest Enemy
- Our War Against Killer Germs
- By: Michael T. Osterholm, Mark Olshaker, Michael T. Osterholm PhD MPH
- Narrated by: Jamie Renell
- Length: 11 hrs and 26 mins
- Unabridged
-
Overall
-
Performance
-
Story
We are facing an overwhelming army of deadly, invisible enemies. We need a plan - before it's too late. Unlike natural disasters, whose destruction is concentrated in a limited area over a period of days, and illnesses, which have devastating effects but are limited to individuals and their families, infectious disease has the terrifying power to disrupt everyday life on a global scale, overwhelming public and private resources and bringing trade and transportation to a grinding halt.
-
-
Topical treatise on virus flu pandemics
- By Wayne on 03-15-20
By: Michael T. Osterholm, and others
-
Phantom Plague
- How Tuberculosis Shaped History
- By: Vidya Krishnan
- Narrated by: Sneha Mathan
- Length: 8 hrs and 53 mins
- Unabridged
-
Overall
-
Performance
-
Story
In Phantom Plague, Vidya Krishnan, traces the history of tuberculosis from the slums of 19th-century New York to modern Mumbai. In a narrative spanning century, Krishnan shows how superstition and folk remedies made way for scientific understanding of TB, such that it was controlled and cured in the West.
-
-
Excellent
- By M. Flanigan on 06-07-23
By: Vidya Krishnan
-
The Vaccine
- Inside the Race to Conquer the COVID-19 Pandemic
- By: Joe Miller, Özlem Türeci, Ugur Sahin
- Narrated by: Nathan Osgood
- Length: 11 hrs and 34 mins
- Unabridged
-
Overall
-
Performance
-
Story
Nobody thought it was possible. In mid-January 2020, Ugur Sahin told Özlem Türeci, his wife and decades-long research partner, that a vaccine against what would soon be known as COVID-19 could be developed and safely injected into the arms of millions before the end of the year. The Vaccine draws back the curtain on one of the most important medical breakthroughs of our age.
-
-
Great story well told
- By James Walters on 06-27-23
By: Joe Miller, and others
-
Paper Belt on Fire
- How Renegade Investors Sparked a Revolt Against the University
- By: Michael Gibson
- Narrated by: Alex Boyles
- Length: 11 hrs and 18 mins
- Unabridged
-
Overall
-
Performance
-
Story
Paper Belt on Fire is the unlikely account of how two outsiders with no experience in finance—a charter school principal and defrocked philosopher—start a venture capital fund to short the higher education bubble. Against the contempt of the education establishment, they discover, mentor, and back the leading lights in the next generation of dropout innovators and in the end make their investors millions. Can such a madcap strategy help renew American creativity? This story is the behind-the-scenes romp of one team that threw educational authorities into a panic.
-
-
Awesome
- By Jamie Keeney on 03-19-23
By: Michael Gibson
-
Horizons
- The Global Origins of Modern Science
- By: James Poskett
- Narrated by: Sid Sagar
- Length: 15 hrs and 18 mins
- Unabridged
-
Overall
-
Performance
-
Story
When we think about the origins of modern science we usually begin in Europe. We remember the great minds of Nicolaus Copernicus, Isaac Newton, Charles Darwin, and Albert Einstein. But the history of science is not, and has never been, a uniquely European endeavor. Copernicus relied on mathematical techniques that came from Arabic and Persian texts. Newton’s laws of motion used astronomical observations made in Asia and Africa. When Darwin was writing On the Origin of Species, he consulted a sixteenth-century Chinese encyclopedia.
-
-
A Woke version of Whig History of Science
- By Trebla on 03-30-22
By: James Poskett
-
Infectious
- Pathogens and How We Fight Them
- By: John Tregoning
- Narrated by: Mike Cooper
- Length: 9 hrs and 35 mins
- Unabridged
-
Overall
-
Performance
-
Story
The subject of infection and how to fight it grows more urgent every day. How do pathogens cause disease? And what tools can we give our bodies to do battle? Dr. John S. Tregoning has dedicated his career to answering these questions. Infectious uncovers fascinating success stories in immunology and virology, making this book not only a vital overview of infection but also a hopeful history of human ingenuity.
-
-
Infectious
- By Amazon Customer on 07-13-23
By: John Tregoning
Critic reviews
“In this highly readable account, [Werb] gives due to those who toiled in obscurity to avert future pandemics only to run into frustrating political roadblocks.”—The Globe and Mail
“One of the most authoritative, comprehensive and, perhaps more importantly, readable books about the behind-the-scenes science of the COVID-19 pandemic and coronaviruses at large.”—The San Diego Union-Tribune
“A fascinating, sometimes terrifying, exploration of science and viruses . . . Through vivid storytelling, we see the deep roots of both scientific discovery and viral ecology, and how these are tangled with human ingenuity and folly.”—David George Haskell, author of The Forest Unseen and The Songs of Trees
2022 Hilary Weston Writers' Trust Non-Fiction Prize, Winner