Dr. Jamison is one of the foremost authorities on manic-depressive (bipolar) illness; she has also experienced it firsthand. For even while she was pursuing her career in academic medicine, Jamison found herself succumbing to the same exhilarating highs and catastrophic depressions that afflicted many of her patients, as her disorder launched her into ruinous spending sprees, episodes of violence, and an attempted suicide.

In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of 19th-century surgery on the eve of profound transformation. She conjures up early operating theaters - no place for the squeamish - and surgeons, working before anesthesia, who were lauded for their speed and brute strength. They were baffled by the persistent infections that kept mortality rates stubbornly high. A young, melancholy Quaker surgeon named Joseph Lister would solve the deadly riddle and change the course of history.

At the age of 27, married, living in New York, and working in book design, Mary Cregan gives birth to her first child, a daughter she names Anna. But it’s apparent that something is terribly wrong, and two days later, Anna dies - plunging Cregan into suicidal despair. Decades later, sustained by her work, a second marriage, and a son, Cregan reflects on this pivotal experience and attempts to make sense of it. She weaves together literature and research with details from her own ordeal - and the still visible scar of her suicide attempt....

An intimate, moving book written with the immediacy and directness of one who still struggles with the effects of mental and chronic illness, The Collected Schizophrenias cuts right to the core. Schizophrenia is not a single unifying diagnosis, and Esmé Weijun Wang writes not just to her fellow members of the “collected schizophrenias” but to those who wish to understand it as well.

Hallucinations don’t belong wholly to the insane. Much more commonly, they are linked to sensory deprivation, intoxication, illness, or injury. Here Dr. Sacks weaves together stories of his patients and of his own mind-altering experiences to illuminate what hallucinations tell us about the organization and structure of our brains, how they have influenced every culture’s folklore and art, and why the potential for hallucination is present in us all.

From the best-selling author of Gratitude and On the Move, a final volume of essays that showcase Sacks's broad range of interests - from his passion for ferns, swimming, and horsetails, to his final case histories exploring schizophrenia, dementia, and Alzheimer's.

A work of great personal courage and a literary tour de force, this bestseller is Styron's true account of his experience of crippling depression. Styron is perhaps the first writer to convey the full terror of depression's psychic landscape, as well as the illuminating path to recovery.

Due to horrible physical deformities, he spent much of his life as a fairground freak. He was hounded, persecuted, and starving, until his fortune changed and he was rescued, housed, and fed by the distinguished surgeon, Frederick Treves. The subject of several books, a Broadway hit, and a film, Joseph Merrick has become part of popular mythology. Here, in this fully revised edition containing much fresh information, are the true and un-romanticized facts of his life.

In his Pulitzer Prize-winning poetry, Robert Lowell put his manic-depressive illness (now known as bipolar disorder) into the public domain, creating a language for madness that was new and arresting. As Dr. Jamison brings her expertise in mood disorders to bear on Lowell’s story, she illuminates not only the relationships among mania, depression, and creativity but also the details of Lowell’s treatment and how illness and treatment influenced the great work that he produced (and often became its subject).

Awakenings - which inspired the major motion picture - is the remarkable story of a group of patients who contracted sleeping sickness during the great epidemic just after World War I. Frozen for decades in a trance-like state, these men and women were given up as hopeless until 1969, when Dr. Oliver Sacks gave them the then-new drug L-DOPA, which had an astonishing, explosive, "awakening" effect. Dr. Sacks recounts the moving case histories of his patients, their lives, and their extraordinary transformations.

Charlotte Brontë's life contained all the drama and tragedy of the great Gothic novels it inspired. Like Jane Eyre, she was raised motherless on remote Yorkshire moors and sent away to a brutally strict boarding school at a young age. Charlotte grew up and watched helplessly as, one by one, her five beloved siblings sickened and died; by the end of her short life, she was the only child of the Brontë clan remaining.

Nietzsche wrote that all philosophy is autobiographical, and in this vividly compelling, myth-shattering biography, Sue Prideaux brings listeners into the world of this brilliant, eccentric, and deeply troubled man, illuminating the events and people that shaped his life and work. I Am Dynamite! is the essential biography for anyone seeking to understand history's most misunderstood philosopher.

Drawing on rarely consulted archives, Crews shows us a man who blundered tragicomically in his dealings with patients, who never produced a corroborated cure, who promoted cocaine in one decade and was deluded by it in the next, who misunderstood the psychological controversies of the era, and who advanced his career through falsifying case histories and betraying the mentors who had helped him to rise.

In his perceptive and moving depiction of Ivan Ilych, a worldly careerist facing his own mortality in the midst of a self-absorbed family and indifferent colleagues, Tolstoy provides one of literature's greatest and most memorable reflections on the meaning of the good life and on life as preparation for death.

For anyone who ever wondered what Marcel Proust had in mind when he wrote the one-and-a-quarter-million words of In Search of Lost Time (while bedridden no less), Alain de Botton has the answer. For, in this stylish, erudite and frequently hilarious book, de Botton dips deeply into Proust’s life and work - his fiction, letter, and conversations – and distils from them that rare self-help manual: one that is actually helpful.