High-powered businesswoman Lana Rubicon has a lot to be proud of: her keen intelligence, impeccable taste, and the L.A. real estate empire she’s built. But when she finds herself trapped 300 miles north of the city, convalescing in a sleepy coastal town with her adult daughter Beth and teenage granddaughter Jack, Lana is stuck counting otters instead of square footage—and hoping that boredom won’t kill her before the cancer does.

One summer morning, twelve-year-old Edward Adler, his beloved older brother, his parents, and 183 other passengers board a flight in Newark headed for Los Angeles. Among them are a Wall Street wunderkind, a young woman coming to terms with an unexpected pregnancy, an injured veteran returning from Afghanistan, a business tycoon, and a free-spirited woman running away from her controlling husband. Halfway across the country, the plane crashes. Edward is the sole survivor.

It’s hard to give up on the feeling that the life you really want is just out of reach. A beach body by summer. A trip to Disneyland around the corner. A promotion on the horizon. Everyone wants to believe that they are headed toward good, better, best. But what happens when the life you hoped for is put on hold indefinitely?

When Boady Sanden first receives the case of Elijah Matthews, he’s certain there’s not much he can do. Elijah, who believes himself to be a prophet, has been locked up in a psychiatric hospital for the past four years, convicted of brutally murdering the pastor of a megachurch. But as a law professor working for the Innocence Project, Boady agrees to look into Elijah’s file. When he does, he is alarmed to find threads that lead back to the death of his colleague and friend, Ben Pruitt, a man shot to death four years earlier in Boady’s own home.

Dr. Tyson Klein is a quantum physicist who has dedicated his entire life to his research. At CERN, he analyses data generated by the Large Hadron Collider, the world's biggest and most powerful particle accelerator. Now, Ty believes he's found a pattern in its output. It looks like an organised data stream, being broadcast over what he calls a quantum radio. Could it be a signal from another universe? A message sent from the future? Or something else entirely?

As Cady struggles under the enormous pressure at Harvard, she investigates her brother’s final year, armed only with a blue notebook of Eric’s cryptic scribblings. She knew he had been struggling with paranoia, delusions, and illusory enemies - but what tipped him over the edge? Voices fill her head, seemingly belonging to three ghosts who passed through the university in life, or death, and whose voices, dreams, and terrors still echo the halls. Among them is a person whose name has been buried for centuries, and another whose name mankind will never forget.

DEA Special Agent Peter Malloy is no stranger to the devastating impact of drugs. So when six bodies turn up with surgical ports implanted in their spines, he's sure a potent new opioid is the culprit. But when lab tests show zero evidence of any known narcotics, he fears something far more sinister. Allison Stevens thought she knew everything about her boss. But after he disappears, she's stunned to discover his secret genetic research in pain tolerance. When she becomes the target of the FBI's investigation, Allison has only one move.

Georgia Brown’s profession as a urologist requires her to interact with plenty of naked men, but her romantic prospects have fizzled. The most important person in her life is her friend Jonah Tsukada, a funny, empathetic family medicine doctor who works at the same hospital in Charleston, South Carolina and who has become as close as family to her. Just after Georgia leaves the country for a medical conference, Jonah shares startling news. The hospital is instructing doctors to stop providing medical care for transgender patients.

When a private plane whisks CDC epidemiologist Madeline Hamilton to Washington, DC, for an urgent medical symposium, she knows something significant is underway - but she doesn’t expect to face the most disturbing medical mystery of her career. A debilitating neurological toxin has stricken the children of several political families, and one of them is the son of US President Anna Moreland.

Juan Gutierrez, a cancer researcher, uncovers what he believes to be the key to conquering humanity's susceptibility to cancer. But others are interested in using the new genetic algorithm for very different applications. Nate Carrington, an FBI forensic analyst, has been struggling with several cold cases when he's alerted to an incident at a nearby ranch. It's a case of a newborn calf who is found in the middle of a herd of dead cattle. It provides a single link to Nate's other cold cases....

Dr. Julie Devereux is an outspoken advocate for the right to die - until a motorcycle accident leaves her fiancé, Sam Talbot, a quadriplegic. Sam begs to end his life, but Julie sees hope in a life together. With the help of an organization that opposes physician-assisted suicide, Julie has Sam coming around to her point of view when he suddenly dies from an unexpected heart attack.

Orphaned and severely deformed, from her earliest moments Sarah Sims has been kept hidden away in a secret CIA facility - until an unexpected discovery gives her an opportunity to make a life for herself at last. Now Sarah has an ally, a long-lost aunt who has discovered her true identity. Aided by this brave psychologist, twenty-year-old Sarah must find the courage to confront the forces that have confined her for so long. And the strength to be reborn into a world she has never known.

Psychology professor Jackie Strelitz thinks she’s over Harlan Crispin, her ex-lover and colleague. Why should she care if Harlan springs a new “friend” on her? After all, Jackie has everything she ever wanted: a loving husband and a thriving career. Still, she can’t help but be curious about Harlan’s latest. Nasira Amari is graceful, smart, and appallingly young. Worse, she’s the newest member of Jackie’s research team.

Hannah Webber fears she will never be a mother, but her prayers are finally answered when she gives birth to a son. Nurturing Sam’s intellect becomes Hannah’s life purpose. She invests body and soul into his development, much to the detriment of her marriage. She convinces herself, however, that Sam’s acceptance to the most prestigious of New England boarding schools justifies her choices. When he arrives at Dunning, Sam enjoys his newfound freedom - until, late one night, he stumbles upon evidence of sexual misconduct at the school and is unable to shake the discovery.

In Massachusetts, neuroscience students Luke, Josh, and Hope have formed an unbreakable and unconditional friendship. Bound by their wit, brilliance, and curiosity, they throw themselves heart and soul into their research. Their new computer program can capture a person’s entire consciousness, memory, and personality - a digital map of the brain’s connections that promises to bridge the relationship between human and machine, between the past and the future. When Hope is diagnosed with a fatal and aggressive illness, their work takes on a new significance and urgency.