Have you ever wondered "Why did I do that?" or "Why can't I just control my behavior?" Others may judge our reactions and think, "What's wrong with that person?" When questioning our emotions, it's easy to place the blame on ourselves; holding ourselves and those around us to an impossible standard. It's time we started asking a different question. Through deeply personal conversations, Oprah Winfrey and renowned brain and trauma expert Dr. Bruce Perry offer a groundbreaking and profound shift from asking “What’s wrong with you?” to “What happened to you?”

Bernadette Fox is notorious. To her Microsoft-guru husband, she's a fearlessly opinionated partner; to fellow private-school mothers in Seattle, she's a disgrace; to design mavens, she's a revolutionary architect, and to 15-year-old Bee, she is a best friend and, simply, Mom.

Then Bernadette disappears. It began when Bee aced her report card and claimed her promised reward: a family trip to Antarctica. But Bernadette's intensifying allergy to Seattle - and people in general - has made her so agoraphobic that a virtual assistant in India now runs her most basic errands.

David Sheff's story is a first: a teenager's addiction from the parent's point of view, a real-time chronicle of the shocking descent into substance abuse and the gradual emergence into hope.

Before meth, Sheff's son, Nic, was a varsity athlete, honor student, and award-winning journalist. After meth, he was a trembling wraith who stole money from his eight-year-old brother and lived on the streets. With haunting candor, Sheff traces the first warning signs, the attempts at rehabilitation, and, at last, the way past addiction. He shows us that, whatever an addict's fate, the rest of the family must care for one another, too, lest they become addicted to addiction.

The first story Selma Blair Beitner ever heard about herself is that she was a mean, mean baby. With her mouth pulled in a perpetual snarl and a head so furry it had to be rubbed to make way for her forehead, Selma spent years living up to her terrible reputation: biting her sisters, lying spontaneously, getting drunk from Passover wine at the age of seven, and behaving dramatically so that she would be the center of attention. In a memoir that is as wildly funny as it is emotionally shattering, Blair tells the captivating story of growing up and finding her truth.

Recently retired WWE superstar AJ Mendez Brooks is a powerhouse - strong, quirky, and totally confident. But that wasn’t always the case. With humor and tremendous heart, she opens up for the first time about her harrowing struggle to understand her demons and the diagnosis that helped her gain control over her life.

Twentysomething Nora McInerny Purmort bounced from boyfriend to boyfriend and job to job. Then she met Aaron, a charismatic art director and her kindred spirit. They made mixtapes (and pancakes) into the wee hours of the morning. They finished each other's sentences. They just knew. When Aaron was diagnosed with a rare brain cancer, they refused to let it limit their love. They got engaged on Aaron's hospital bed and married after his first surgery. They had a baby when he was on chemo.

Written by Deborah Ziegler, the mother of Brittany Maynard - a 29-year-old woman with a terminal brain tumor - this touching and beautiful memoir captures and celebrates her daughter's spirit and the mostly untold story of Brittany's last year of life as she chose her right to die with dignity, a journey that inspired millions.

In the span of four months in 2012, Tig Notaro was hospitalized for a debilitating intestinal disease called C. diff, her mother unexpectedly died, she went through a breakup, and then she was diagnosed with bilateral breast cancer. Hit with this devastating barrage, Tig took her grief onstage. Days after receiving her cancer diagnosis, she broke new comedic ground, opening an unvarnished set with the words, "Good evening. Hello. I have cancer. How are you? Hi, how are you? Is everybody having a good time? I have cancer."

Kim Miller is an immaculately put-together woman with a great career, a loving boyfriend, and a tidy apartment on Manhattan’s Upper West Side. You would never guess that Kim grew up behind the closed doors of her family’s idyllic Long Island house, navigating between teetering stacks of aging newspapers, broken computers, and boxes upon boxes of unused junk festering in every room - the product of her father’s painful and unending struggle with hoarding. In this moving coming-of-age story, Kim brings to life her rat-infested home and her childhood consumed by concealing her father’s shameful secret from friends.

Everybody knows that Patricia Heaton plays the hilarious, wise, and tempestuous married-with-kids everywoman on Everybody Loves Raymond. What they might not know is that in real life, she is married, has four boys under eight years old, and is just as funny offscreen as on. Motherhood and Hollywood is Patricia Heaton’s humorous and poignant collection of essays on life, love, marriage, child-rearing, show business, having parents, being a parent, spousal rage, surviving fame, success, and the shame of underarm flab. She is warm, witty, and refreshingly irreverent.

Growing up, Jenny Pentland’s life was a literal sitcom. Many of the storylines for her mother’s smash hit series, Roseanne, were drawn from Pentland’s early family life in working-class Denver. But that was only the beginning of the drama. Roseanne Barr’s success as a comedian catapulted the family from the Rockies to star-studded Hollywood—with its toxic culture of money, celebrity, and prying tabloids that was destabilizing for a child in grade school.

As a daughter, mother, and friend, Mary Laura Philpott considered herself an “anxious optimist”—a natural worrier with a stubborn sense of good cheer. And while she didn’t really think she had any sort of magical protective powers, she believed in her heart that as long as she loved her people enough, she could keep them safe.

It began in Los Angeles in 1993, when Jaime Lowe was just 16. She stopped sleeping and eating and began to hallucinate - demonically cackling Muppets, faces lurking in windows, Michael Jackson delivering messages from the Neverland Underground. Lowe wrote manifestos and math equations in her diary and drew infographics on her bedroom wall. Eventually hospitalized and diagnosed as bipolar, she was prescribed a medication that came in the form of three pink pills - lithium.

In 1972, at the age of 21, John Callahan was involved in a car crash that severed his spine and made him a quadriplegic. A heavy drinker since the age of 12, the accident could have been the beginning of a downward spiral. Instead, it sparked a personal transformation. After extensive physical therapy, he was eventually able to grasp a pen in his right hand and make rudimentary drawings. By 1978, Callahan had sworn off drinking for good and begun to draw cartoons. Over the next three decades, Callahan would become one of the nation's most beloved cartoonists.

Rob Delaney is a comedy superstar. But if you’re ever watched him steal scenes as Peter in Deadpool 2, binged his streaming series Catastrophe, encountered his raunchy and mischievous Twitter presence, or witnessed the hilarious and painful sharing he does in his stand-up, you already know that. In his first book, he traces his journey from middle-class theater geek to public menace to devoted family man and passionately engaged model citizen.