A year after her divorce, Joyce is settling into being single again. She likes her job archiving family photos and videos, and she’s developed a secret comforting hobby: trolling the neighborhood social networking site, Small World, for posts that help solve life’s easiest problems. When her older sister Lydia, also divorced, calls to tell her she’s moving back east from Los Angeles after almost thirty years away, Joyce invites Lydia to move into her Cambridge apartment. Temporarily. Just until she finds a place of her own.

In a sleepy seaside town in Maine, recently widowed Eveleth "Evvie" Drake rarely leaves her large, painfully empty house nearly a year after her husband’s death in a car crash. Everyone in town, even her best friend, Andy, thinks grief keeps her locked inside, and Evvie doesn’t correct them. Meanwhile, in New York City, Dean Tenney, former Major League pitcher and Andy’s childhood best friend, is wrestling with what miserable athletes living out their worst nightmares call the "yips": he can’t throw straight anymore, and, even worse, he can’t figure out why.

Twelve-year-old Norman Foreman and his best friend, Jax, are a legendary comedic duo in waiting, with a plan to take their act all the way to the Edinburgh Fringe. But when Jax dies, Norman decides the only fitting tribute is to perform at the festival himself. The problem is, Norman’s not the funny one. Jax was.

It’s 2 AM on a Saturday night in the spring of 2001, and 28-year-old Cecily Gardner sits alone in a dive bar in New York’s East Village, questioning her life. Feeling lonesome and homesick for the Midwest, she wonders if she’ll ever make it as a reporter in the big city - and whether she made a terrible mistake in breaking up with her longtime boyfriend, Matthew.

In the spring of 2020, Lara’s three daughters return to the family's orchard in Northern Michigan. While picking cherries, they beg their mother to tell them the story of Peter Duke, a famous actor with whom she shared both a stage and a romance years before at a theater company called Tom Lake. As Lara recalls the past, her daughters examine their own lives and relationship with their mother, and are forced to reconsider the world and everything they thought they knew.

At times stern, at other times patient, at times perceptive, at other times in sad denial, Olive Kitteridge, a retired schoolteacher, deplores the changes in her little town of Crosby, Maine, and in the world at large, but she doesn’t always recognize the changes in those around her: a lounge musician haunted by a past romance; a former student who has lost the will to live; Olive’s own adult child, who feels tyrannized by her irrational sensitivities; and her husband, Henry, who finds his loyalty to his marriage both a blessing and a curse.

Sasha has had it. She cannot bring herself to respond to another inane, “urgent” email or participate in the corporate employee joyfulness program. She hasn’t seen her friends in months. Sex? Seems like a lot of effort. Even cooking dinner takes far too much planning. Sasha has hit a wall. Armed with good intentions to drink kale smoothies, try yoga, and find peace, she heads to the seaside resort she loved as a child. But it’s the off season, the hotel is in a dilapidated shambles, and she has to share the beach with the only other occupant: a grumpy guy named Finn.

For Sewanee Chester, being an audiobook narrator is a long way from her old dreams, but the days of being a star on film sets are long behind her. She’s found success and satisfaction from the inside of a sound booth and it allows her to care for her beloved, ailing grandmother. When she arrives in Las Vegas last-minute for a book convention, Sewanee unexpectedly spends a whirlwind night with a charming stranger.

One summer morning, twelve-year-old Edward Adler, his beloved older brother, his parents, and 183 other passengers board a flight in Newark headed for Los Angeles. Among them are a Wall Street wunderkind, a young woman coming to terms with an unexpected pregnancy, an injured veteran returning from Afghanistan, a business tycoon, and a free-spirited woman running away from her controlling husband. Halfway across the country, the plane crashes. Edward is the sole survivor.

Jacquie Red Feather is newly sober and trying to make it back to the family she left behind in shame. Dene Oxendene is pulling his life back together after his uncle's death and has come to work at the powwow to honor his uncle's memory. Opal Viola Victoria Bear Shield has come to watch her nephew Orvil, who has taught himself traditional Indian dance through YouTube videos and will perform in public for the very first time. There will be glorious communion and a spectacle of sacred tradition and pageantry. And there will be sacrifice, and heroism, and loss.

Hidden in the depths of eighteenth-century London, a secret apothecary shop caters to an unusual kind of clientele. Women across the city whisper of a mysterious figure named Nella who sells well-disguised poisons to use against the oppressive men in their lives. But the apothecary’s fate is jeopardized when her newest patron, a precocious 12-year-old, makes a fatal mistake, sparking a string of consequences that echo through the centuries.

Since she was nine years old, Alina Dziak knew she would marry her best friend, Tomasz. Now 15 and engaged, Alina is unconcerned by reports of Nazi soldiers at the Polish border, believing her neighbors that they pose no real threat, and dreams instead of the day Tomasz returns from college in Warsaw so they can be married. But little by little, injustice by brutal injustice, the Nazi occupation takes hold, and Alina’s tiny rural village, its families, are divided by fear and hate. Then, as the fabric of their lives is slowly picked apart, Tomasz disappears.

In present-day New York City, five women meet in a basement support group to process their traumas. Bernice grapples with the fallout of dating a psychopathic, blue-bearded billionaire. Ruby, once devoured by a wolf, now wears him as a coat. Gretel questions her memory of being held captive in a house made of candy. Ashlee, the winner of a Bachelor-esque dating show, wonders if she really got her promised fairy tale ending. And Raina's love story will shock them all.

The Delaneys are fixtures in their community. The parents, Stan and Joy, are the envy of all of their friends. They’re killers on the tennis court, and off it their chemistry is palpable. But after 50 years of marriage, they’ve finally sold their famed tennis academy and are ready to start what should be the golden years of their lives. So why are Stan and Joy so miserable?

Ernt Allbright, a former POW, comes home from the Vietnam war a changed and volatile man. When he loses yet another job, he makes an impulsive decision: He will move his family north, to Alaska, where they will live off the grid in America’s last true frontier.