This is the story of Pierre Tradivel, a scientist, and his complex battle against deadly illness, and ex-Nazi war criminal still hiding in the U.S., a crooked insurance company, and a plot to make Pierre and his wife the victims of a bizarre genetic experiment. Frameshift is hard science fiction at its best, full of complications and neat surprises.

In 2059, two vastly different groups of people portrayed by the compelling trio of Brendan Fraser (Academy Award winner), Luke Kirby (Emmy Award winner), and Vanessa Sears (Dora Award winner) undergo cryonic suspension. While their bodies are frozen, their minds, still active and awake, are uploaded into a massive quantum computer. The first group are all astronauts, about to leave Earth on a one-way interstellar colonization mission. The second group consists of convicted murderers and volunteers who elect to serve their sentences in a virtual-reality prison.

Experimental psychologist Jim Marchuk has developed a flawless technique for identifying the previously undetected psychopaths lurking everywhere in society. But while being cross-examined about his breakthrough in court, Jim is shocked to discover that he has lost his memories of six months of his life from 20 years previously - a dark time during which he himself committed heinous acts.

In the near future, a signal is detected coming from the Alpha Centauri system. Mysterious, unintelligible data streams in for ten years. Heather Davis, a professor in the University of Toronto psychology department, has devoted her career to deciphering the message. Her estranged husband, Kyle, is working on the development of artificial intelligence systems and new computer technology utilizing quantum effects to produce a near-infinite number of calculations simultaneously.

When a disabled spaceship enters Earth's atmosphere, seven members of the advanced Tosok race are welcomed by the world. Then a popular scientist is murdered, and all evidence points to one of the Tosoks. Now, an alien is tried in a court of law -and there may be far more at stake than accounting for one human life.