On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

Through public triumphs and private sorrows, the men in the Sisters' lives - husbands, friends, colleagues, and lovers - have offered invaluable aid and support. In the process, they've become an informal brotherhood of their own, able to relate to the unique challenges and rewards of life among the vigilantes.

After years of trying to become pregnant without success, Rachel Dawson and her husband Thomas felt their dreams had finally come true the day they brought home their newly adopted twin babies. Though the lawyer Baron Bell who arranged for the surrogate mother charged a hefty six-figure fee, one glance into the eyes of their precious children told them it was all worth it - until the birth mother reappeared, first demanding more money, then the twins themselves.

Mateo Castillo is a rising star chef on the Manhattan culinary scene. But just as he’s about to reap the rewards of his skill and hard work by being featured on a major TV cooking competition, Mateo collapses in his restaurant’s kitchen—and regains consciousness in a hospital emergency room. If it weren’t for a security guard finding him in time, Mateo would have bled to death. The cause of his sudden illness is as mysterious as it is worrying, and Mateo and his family undergo a battery of genetic tests. Yet the answers that start to emerge only raise more questions.

On the eve of her retirement, Georgia attorney Mikala Aulani is as vivacious and vibrant as ever, eagerly anticipating a happy future with her partner, Ben. But if Kala has learned anything in 35 years of practicing law, it’s that the truth can always surprise you. And when Adam Star turns up at her office, confessing to the long-ago murder of his wife, Kala must return to a notorious case that has never stopped haunting her. Ten years have passed since young nurse Sophie Lee was accused of murdering her wealthy patient.

Teresa "Toots" Amelia Loudenberry has crammed a great deal of living - not to mention eight much-loved husbands - into her varied and rewarding life. Newly single, Toots is ready to taste life again, and fate has just handed her the perfect opportunity.

Olivia Lowell always believed her father's claim that her mother died in childbirth, until the shocking day a lawyer informs her that her mother has just passed away, leaving her a fortune. The money comes with a caveat - and a confession. In her will, Olivia's mother reveals that she and two college friends committed a crime long ago, and now she wants Olivia to track down her accomplices and convince them to come clean.

Satisfied with her life and a new relationship, Abby Mitchell is most happy to be reunited with her sister, who was separated from her after their parents died. The siblings are planning a sumptuous party, unaware that an uninvited guest is coming, one who'll do anything to help keep the past hidden.

Kate and Alex Rocket are blessed with a wonderful marriage and a lovely home. Although Kate is unable to bear children, she and Alex look upon Sara and Emily, affectionate daughters of their good friends Don and Debbie Winter, as part of their family. With one phone call, everything changes. Sara accuses Alex of a heinous act, opening up a vicious rift between the couples. In a single moment an idyllic all-American life has imploded into an unfathomable nightmare. Kate can only watch helplessly as her innocent husband is convicted and sent to prison.

As far as former NFL star Jake Masters is concerned, dreams are risky propositions. Years ago he came achingly close to achieving his ambition of playing in the Super Bowl - before a spinal injury ended his career. Confined to a wheelchair, unwilling to take a chance on another risky surgery that could restore his mobility, Jake now stays cocooned behind the imposing gates of his lavish home.

Darby Lane and Russell Gunn had been inseparable friends since their days in the Horseshoe, the wonderful Baton Rouge neighborhood of their youth. But after graduate school, a tragic accident takes Russ’s life - and Darby’s world is shattered. Her long journey to healing brings her closer to Russ’s brother Ben, whom she begins to see through new eyes. Suddenly love blooms in the place of grief; and now, with the help of the three wily and colorful aunts who raised her, Darby faces the challenge of reuniting Ben with his estranged father....

Professional mountaineer Lily is building a new life for herself - in ways she never would have expected. She's traded the mountain wilderness of Wyoming for the lush river country of the deep South, where she is busy restoring a fine old Natchez, Mississippi house. And she's rediscovered happiness with Matt Starr, the man she has always loved. But Lily's dreams for the future are suddenly threatened when Matt disappears without a trace.

At 29, Alison Marshall is ready to find a place to call home. With no family and no ties, she’s drifted from one small Florida town to another since high school, working odd jobs, saving hard, and building a nest egg. Once she finds the right place to settle down, she’ll know. And when she reaches beautiful Palmetto Island, she thinks she may have found it. The small, close-knit island community seems to have everything Alison needs. On a hunch, she contacts the island’s only realtor, and learns that an old beach house is on the market.

Gus Hollister owes all his success to his feisty grandmother, Rose, and he knows it. It was Rose and her two sisters, Iris and Violet, who raised Gus, sent him to the best schools, and helped him start his own accounting business. Rose even bought the house Gus lives in with his wife, Elaine. But now, Gus stands to lose everything - his home, his car, and his business. Worse, he’s alienated his beloved grandma, who tried to warn him about Elaine’s greedy, gold-digging ways.

On his thirty-fifth birthday, Jake St. Cloud inherits a fortune - and learns the whereabouts of his mysterious half-brother. On her deathbed, Selma St. Cloud revealed that Jake had a sibling, a product of his father's affair. At last, Jake is in a position to track down Alex Rosario and make amends for their father's past neglect.