Three middle-aged women who have seen their carefully crafted lives take a precipitous financial plunge, forge an unlikely friendship while getting paid to take part in a clinical trial for a new menopause drug. The trio spends a month sequestered at a pharmaceutical testing facility that has all the charm of a nail salon inside a Walmart, and bond over their anger and disbelief that their only hope for some quick cash is leveraging the remaining estrogen they have lurking in their ovaries.

High-powered businesswoman Lana Rubicon has a lot to be proud of: her keen intelligence, impeccable taste, and the L.A. real estate empire she’s built. But when she finds herself trapped 300 miles north of the city, convalescing in a sleepy coastal town with her adult daughter Beth and teenage granddaughter Jack, Lana is stuck counting otters instead of square footage—and hoping that boredom won’t kill her before the cancer does.

Jill and Derick knew a normal life wasn’t possible for them. As a star on the popular TLC reality show 19 Kids and Counting, Jill grew up in front of viewers who were fascinated by her family’s way of life. She was the responsible, second daughter of Jim Bob and Michelle’s nineteen kids; always with a baby on her hip and happy to wear the modest ankle-length dresses with throat-high necklines.

When Holly White's fiancé cancels their Christmas Eve wedding with less than two weeks to go, Holly heads home with a broken heart. Lucky for her, home in historic Mistletoe, Maine is magical during Christmastime - exactly what the doctor prescribed. Except her plan to drown her troubles in peppermints and snickerdoodles is upended when local grouch and president of the Mistletoe Historical Society, Margaret Fenwick, is bludgeoned and left in the sleigh display at Reindeer Games, Holly's family tree farm.

At age 26 Agatha Raisin has already come a long way. She has clawed her way up since leaving the Birmingham slum where she was born. She's lost her Birmingham accent, run away from her drunken husband, and found a job at a public relations office as a secretary. Then her boss asks Agatha to go to the home of Sir Bryce Teller to tell him that he is soon to be arrested for the murder of his wife and that the agency no longer wants to represent him.

The megatalented creator of Grey's Anatomy and Scandal and executive producer of How to Get Away with Murder chronicles how saying yes for one year changed her life - and how it can change yours, too.

Michele's lack of focus in life hasn't bothered her, until the day she finds herself with mounting credit card debt, unable to afford her rent, and without a job. While her meddling family questions how she can end up in this predicament, at the age of 29, and single to boot, Michele doesn't want to admit the truth. All she wants to do is sew. Faced with the prospect of moving back into her parents' house, Michele throws a Hail Mary pass and applies for a TV design contest, Made for Me.

To the untrained eye, Cleopatra Gallier appears to lead a charmed life in Honolulu's paradise. She is impossibly beautiful, clever, wealthy and...trained to kill. When she enters into a love affair with the much younger, irresistibly handsome rogue, Jake Regan, she finds herself colliding with an intricate terrorist plot. Her secret past, like Hawaii's smoldering volcano, is ready to erupt. In the four days leading up to Christmas, two stunning betrayals and a terrorist attack threaten to reduce her and the island she loves to ashes.

Overworked and underappreciated, single mom Amy Byler needs a break. So when the guilt-ridden husband who abandoned her shows up and offers to take care of their kids for the summer, she accepts his offer and escapes rural Pennsylvania for New York City. Usually grounded and mild mannered, Amy finally lets her hair down in the city that never sleeps. She discovers a life filled with culture, sophistication, and - with a little encouragement from her friends - a few blind dates.

Jude and Lauren don't have much in common, but maybe that's why they've been best friends since the third grade. Through ups and downs, they've been by each other's sides. But now? They’re broke, single, and do the only thing that makes sense - move in together, just like they talked about when they were teenagers. Except when they were younger, the plan didn't include a five-year-old daughter and more baggage than their new townhouse can hold.

My name is Calliope and "I bone for a living." Kidding. I am studying to be a paleontologist though. It's the only thing I've ever wanted to be, and I have finally landed the perfect museum internship to make all of my dino-loving dreams come true. Trouble is, everyone wants me to be a gentle, loving sort of creature, but I'm more of the T-Rex type by nature - the kind who is determined to stomp and tear her way through any obstacle in order to get what she wants.

Natalie is a Bloomingdale's salesgirl mooning over her lawyer ex-boyfriend, who's engaged to someone else after just two months. Felicia has been quietly in love with her boss for 17 years and has one night to finally make the feeling mutual. Andie is a private detective who specializes in gathering evidence on cheating husbands - a skill she unfortunately learned from her own life - and lands a case that may restore her faith in true love.

When Georgie discovers that her fiancé has been cheating on her, only a few days before her cousin’s wedding, her whole world explodes. Facing a romantic trip to Vegas alone, she decides to go out and have some fun…but Georgie never expected to wake up wed! And even worse, she can’t remember who to. So when gorgeous Jack reveals himself as her husband, she can’t believe her luck – he’ll act as the perfect wedding date!

Best friends, Casey and Rachel couldn't lead more different lives. While workaholic Casey rubs elbows with celebrities daily as the host of Gossip TV and comes home nightly to an empty apartment, stay-at-home mom Rachel juggles a baby, two teenagers, and a husband who barely seems the man she fell in love with two decades before. After an argument at their 20th high school reunion, Casey and Rachel throw back shots to get the night back on track. Instead, they get a life-changing hangover.

Jen Dixon is not your typical Kansas City kindergarten class mom - or mom in general. Jen already has two college-age daughters by two different (probably) musicians, and it's her second time around the class mom block with five-year-old Max - this time with a husband and father by her side. Though her best friend and PTA president sees her as the "wisest" candidate for the job (or oldest), not all of the other parents agree.