In the turbulent summer of 1974, Kate Mularkey has accepted her place at the bottom of the eighth-grade social food chain. Then, to her amazement, the "coolest girl in the world" moves in across the street and wants to be her friend. Tully Hart seems to have it all - beauty, brains, ambition. On the surface they are as opposite as two people can be: Kate, doomed to be forever uncool, with a loving family who mortifies her at every turn.

For 18 years, Jude Farraday has put her children’s needs above her own, and it shows - her twins, Mia and Zach, are bright and happy teenagers. When Lexi Baill moves into their small, close-knit community, no one is more welcoming than Jude. Lexi, a former foster child with a dark past, quickly becomes Mia’s best friend. Then Zach falls in love with Lexi and the three become inseparable. Jude does everything to keep her kids on track for college and out of harm’s way. It has always been easy - until senior year of high school. Suddenly she is at a loss.

As a teenager at the prestigious Bradley School, Ani FaNelli endured a shocking, public humiliation that left her desperate to reinvent herself. Now, with a glamorous job, expensive wardrobe, and handsome blue blood fiancé, she’s this close to living the perfect life she’s worked so hard to achieve. But Ani has a secret. There’s something else buried in her past that still haunts her, something private and painful that threatens to bubble to the surface and destroy everything.

In 1985, Yale Tishman, the development director for an art gallery in Chicago, is about to pull off an amazing coup, bringing in an extraordinary collection of 1920s paintings as a gift to the gallery. Yet as his career begins to flourish, the carnage of the AIDS epidemic grows around him. One by one, his friends are dying and after his friend Nico's funeral, the virus circles closer and closer to Yale himself. Soon the only person he has left is Fiona, Nico's little sister.

Being the middle child has its ups and downs. But for Grace, an only child who was adopted at birth, discovering that she is a middle child is a different ride altogether. After putting her own baby up for adoption, she goes looking for her biological family, including: Maya, her loudmouthed younger bio sister, who has a lot to say about their newfound family ties. And Joaquin, their stoic older bio brother, who has no interest in bonding over their shared biological mother.

Rachel Blum and Andy Landis are eight years old when they meet late one night in an ER waiting room. Born with a congenital heart defect, Rachel is a veteran of hospitals, and she's intrigued by the boy who shows up all alone with a broken arm. He tells her his name. She tells him a story. After Andy's taken back to the emergency room and Rachel's sent back to her bed, they think they'll never see each other again.

In the spring of 1981, the young Skinner siblings - fierce Renee, dreamy Caroline, golden boy Joe, and watchful Fiona - lose their father to a heart attack and their mother to a paralyzing depression, events that thrust them into a period they will later call “the Pause”. Caught between the predictable life they once led and an uncertain future that stretches before them, the siblings navigate the dangers and resentments of the Pause to emerge fiercely loyal and deeply connected. Two decades later, the Skinners find themselves again confronted with a family crisis....

Two cousins, Rory and Arden, lie unconscious in a hospital burn unit. The fire, which broke out in their shared college dorm room, killed another student, and the police want answers. Tension between Rory and Arden's parents was already at an all-time high before the fire, owing to a recent financial crisis and the decline of the family business. As the parents huddle anxiously in the waiting room, carefully avoiding the subject of their own unraveling relationships, disturbing truths come to light.

He was tall, at least six feet, with dirty blond hair that hung over his eyes. His T-shirt read Nietzsche Is My Homeboy. So, that was Matt. Who Julie Seagles likes. A lot. But there is also Finn. Who she flat out loves. Complicated? Awkward? Completely. But really, how was this freshly-minted Boston transplant and newbie college freshman supposed to know that she would end up living with the family of an old friend of her mother’s? This was all supposed to be temporary.

Dr. Olivia Simon is on duty in the emergency room of North Carolina's Outer Banks Hospital when a gunshot victim is brought in. Midway through the desperate effort to save the young woman's life, Olivia realizes who she is - Annie O'Neill, the woman Olivia's husband, Paul, is in love with.

Helena Conway has fallen in love. Unwillingly. Unwittingly. But not unprovoked. Kit Isley is everything she's not - unstructured, untethered, and not even a little bit careful. It could all be so beautiful...if he wasn't dating her best friend. Helena must defy her heart, do the right thing, and think of others. Until she doesn't.

Lorraine—“Rainy”—lives at the top of Tiger Mountain. Remote, moody, cloistered in pine trees and fog, it’s a sanctuary, a new life. She can hide from the disturbing past she wants to forget. If she’s allowed to. When Rainy reluctantly agrees to a girls’ weekend in Vegas, she’s prepared for an exhausting parade of shots and slot machines. But after a wild night, her friend Braithe doesn’t come back to the hotel room.

Seventeen-year-old Evan Panos doesn't know where he fits in. His strict immigrant Greek mother refuses to see him as anything but a disappointment. His quiet, workaholic father is a staunch believer in avoiding any kind of conflict. And his best friend, Henry, has somehow become distractingly attractive over the summer.

Fifteen years ago, Vida Avery arrived alone and pregnant at elite Fayer Academy. By living on campus, on an island off the New England coast, Vida has cocooned herself and her son, Peter, from the outside world and from an inside secret. For years, she has lived largely through the books she teaches, but when she accepts the impulsive marriage proposal of ardent widower Tom Belou, the prescribed life Vida has constructed is swiftly dismantled.

I’ve been listening to my father sing for my whole life. I carry him in my pocket on my MP3 player. It’s just that we’ve never met face to face. My mother would never tell me how I came to be, or why my rock star father and I have never met. I thought it was her only secret. I was wrong. When she dies, he finally appears. Suddenly I have a first-class ticket into my father’s exclusive world. A world I don’t want any part of - not at this cost. Only three things keep me going: my a cappella singing group, a swoony blue-eyed boy named Jake, and the burning questions in my soul.