Set in the mountains of southern Appalachia, Demon Copperhead is the story of a boy born to a teenaged single mother in a single-wide trailer, with no assets beyond his dead father’s good looks and copper-colored hair, a caustic wit, and a fierce talent for survival. Relayed in his own unsparing voice, Demon braves the modern perils of foster care, child labor, derelict schools, athletic success, addiction, disastrous loves, and crushing losses.

Irene, a lonely 19-year-old in rural North Carolina, works long nights at the local pool hall, serving pitchers and dodging drunks. One evening, her hilarious, magnetic coworker Luce invites her on a joyride through the mountains to take revenge on a particularly creepy customer. Their adventure not only spells the beginning of a dazzling friendship, it seduces both girls into the mysterious world of pills and the endless hustles needed to fund the next high.

For nearly a decade, twenty-nine-year-old Hudson Miller has made his living in the boxing ring, but a post-fight brawl threatens to derail his career. Desperate for money, Hudson takes a gig as a bouncer at a dive bar. That’s when life delivers him another hook to the jaw: his estranged father, Leland, has been murdered in what appears to be a robbery-gone-bad at his salvage yard, Miller’s Pull-a-Part.

Miles is a Vietnam vet who’s worried he’s going to lose his job and his tenuous grasp on a stable life because of a fight he had with a coworker over some steroids. His PTSD and struggles to control his steroid-fueled violent tendencies complicate life with his girlfriend, Shelby, a stripper who only occasionally seems to have the proverbial heart of gold. She certainly seems to possess more kindness and generosity than her brother, Wylie, who’s currently on the run after being implicated in the deaths of two local oxycodone dealers and has their relatives on his tail.

Billy Summers is a man in a room with a gun. He’s a killer for hire and the best in the business. But he’ll do the job only if the target is a truly bad guy. And now Billy wants out. But first there is one last hit. Billy is among the best snipers in the world, a decorated Iraq war vet, a Houdini when it comes to vanishing after the job is done. So what could possibly go wrong?

Everyone says the Elders family are nothing but cheats, thieves, and convicts - a fact 19-year-old Jamie Elders has been trying desperately to escape. She may have the natural talent of a poker savant, but her dreams of going pro and getting the hell out of the tiny town of Blind River, New York, are going nowhere fast - especially when she lands in a huge pile of debt to her uncle Loyal. At Loyal's beck and call until her debt is repaid, Jamie can't easily walk away - not with her younger brother Toby left at his mercy.

Dane Kirby is a broken man and no stranger to tragedy. As a life-long resident and ex-arson investigator for McFalls County, Dane has lived his life in one of the most chaotic and crime-ridden regions of the south. When he gets called in to consult on a brutal murder in a Jacksonville, Florida, motel room, he and his FBI counterpart, Special Agent Roselita Velasquez, begin an investigation that leads them back to the criminal circles of his own backyard.

Teancum Leon, who goes by Tean, is a wildlife veterinarian. His life has settled into a holding pattern: He loves his job, he hates first dates, and he only occasionally has to deal with his neighbor Mrs. Wish’s cat-related disasters. All of that changes, though, when a man appears in his office, asking for help to find his brother. Jem is convinced that something bad has happened to Benny, and he thinks Tean might be able to help. Tean isn’t sure, but he’s willing to try. After all, Jem is charming and sweet and surprisingly vulnerable. Oh. And hot.

Richard Dane has killed a man. He cannot unhear the firing of the gun or unsee the blood on his living room wall. But everybody in the small town of LaBorde, Texas, knows Dane acted in self-defense. Everybody except Ben Russel, the ex-con father of the small-time criminal who invaded Dane's home. When Russel comes looking for revenge against Dane's family, the two are unexpectedly drawn into a conspiracy that conceals the vilest of crimes.

Barely 30, Lynette is exhausted. Saddled with bad credit and juggling multiple jobs, some illegally, she’s been diligently working to buy the house she lives in with her mother and developmentally disabled brother Kenny. Portland’s housing prices have nearly quadrupled in 15 years, and the owner is giving them a good deal. Lynette knows it’s their last best chance to own their own home - and obtain the security they’ve never had. While she has enough for the down payment, she needs her mother to cover the rest of the asking price.

For Mike Muñoz, a young Chicano living in Washington State, life has been a whole lot of waiting for something to happen. Not too many years out of high school and still doing menial work - and just fired from his latest gig as a lawn boy on a landscaping crew - he knows that he's got to be the one to shake things up if he's ever going to change his life. But how?

Virgil Wounded Horse is the local enforcer on the Rosebud Indian Reservation in South Dakota. When justice is denied by the American legal system or the tribal council, Virgil is hired to deliver his own punishment, the kind that’s hard to forget. But when heroin makes its way into the reservation and finds Virgil’s own nephew, his vigilantism suddenly becomes personal. He enlists the help of his ex-girlfriend and sets out to learn where the drugs are coming from, and how to make them stop.

Rufus O’Callaghan has eked out a living on the streets of New York City by helping the police put away criminals as a confidential informant. But when Rufus shows up for an arranged meeting and finds his handler dead, his already-uncertain life is thrown into a tailspin. Now someone is trying to kill Rufus too, and he’s determined to find out why.

It was the summer of 1965. Ray, Tim, and Jennifer were just three teenage friends hanging out in the campgrounds, drinking a little. But Tim and Jennifer didn't know what their friend Ray had in mind. And if they'd known, they wouldn't have thought he was serious. Then they saw what he did to the two girls at the neighboring campsite - and knew he was dead serious...Ray figured he was in the clear. Tim and Jennifer thought the worst was behind them, that the horrors were all in the past. They were wrong. The worst was yet to come.

Auggie is starting his first year at Wroxall College. It’s a punishment, and he’s determined to make his way through the year, prove himself, and earn the right to go back home. Theo is a grad student recovering from a terrible car accident. He’s lost his husband and their daughter, and he’s trying to figure out how to keep going. When both are tangled up in a murder, though, they have to set their personal problems aside and work together — first to clear their names, and then, when the killer turns his attention on them, to survive.