Iris Hollow and her two older sisters are unquestionably strange. Ever since they disappeared on a suburban street in Scotland as children only to return a month a later with no memory of what happened to them, odd, eerie occurrences seem to follow in their wake. And they're changing. First, their dark hair turned white. Then, their blue eyes slowly turned black. They have insatiable appetites yet never gain weight. People find them disturbingly intoxicating, unbearably beautiful, and inexplicably dangerous.

The Yaga siblings—Bellatine, a young woodworker, and Isaac, a wayfaring street performer and con artist—have been estranged since childhood, separated both by resentment and by wide miles of American highway. But when they learn that they are to receive an inheritance, the siblings agree to meet—only to discover that their bequest isn’t land or money, but something far stranger: a sentient house on chicken legs.

A diary, written in 1912 by a Lutheran Pastor is discovered within a wall. What it unveils is a slow massacre, a chain of events that go back to 217 Blackfeet dead in the snow. Told in transcribed interviews by a Blackfeet named Good Stab, who shares the narrative of his peculiar life over a series of confessional visits. This is an American Indian revenge story written by one of the new masters of horror, Stephen Graham Jones.

The Lady knows the stories: how her eyes induce madness in men. The Lady knows she will be wed to the Scottish brute, who does not leave his warrior ways behind when he comes to the marriage bed. The Lady knows his hostile, suspicious court will be a game of strategy, requiring all of her wiles and hidden witchcraft to survive. But the Lady does not know her husband has occult secrets of his own. She does not know that prophecy girds him like armor. She does not know that her magic is greater and more dangerous, and that it will threaten the order of the world.

From her cell in a mysterious convent, a woman writes the story of her life in whatever she can find—discarded ink, dirt, and even her own blood. A lower member of the Sacred Sisterhood, deemed an unworthy, she dreams of ascending to the ranks of the Enlightened at the center of the convent and of pleasing the foreboding Superior Sister. Outside, the world is plagued by catastrophe—cities are submerged underwater, electricity and the internet are nonexistent, and bands of survivors fight and forage in a cruel, barren landscape. Inside, the narrator is controlled, punished, but safe.