When a private plane whisks CDC epidemiologist Madeline Hamilton to Washington, DC, for an urgent medical symposium, she knows something significant is underway - but she doesn’t expect to face the most disturbing medical mystery of her career. A debilitating neurological toxin has stricken the children of several political families, and one of them is the son of US President Anna Moreland.

Talking about death and dying is considered taboo in polite company, and even in the medical field. Our ideas about dying are confusing at best: Will our memories flash before our eyes? Regrets consume our thoughts? Does a bright light appear at the end of a tunnel? For most people, it will be a slower process, one eased with preparedness, good humor, and a bit of faith. At the forefront of changing attitudes around palliative care is hospice nurse Hadley Vlahos, who shows that end-of-life care can teach us just as much about how to live as it does about how we die.

A woman is found naked, badly beaten and barely alive in the New Mexico mountains. The shocking discovery plunges Albuquerque Detective Alyssa Wyatt into a case that will test her to the limit. It appears that Callie McCormick is the latest plaything of a shadowy psychopath that leaves a long shadow on the streets of New Mexico - an individual linked to a string of deaths but leaving no evidence. But when Alyssa makes a breakthrough that just might reveal the killer, she unknowingly puts herself in the crosshairs of a brutal maniac - one with an old score to settle.

It’s the worst possible time for Detective Kerri Devlin to be involved in an all-consuming double-homicide case. She’s locked in a bitter struggle with her ex-husband and teenage daughter, and her reckless new partner is anything but trustworthy. Still, she has a job to do: There’s a killer at large, and a pregnant woman has gone missing. Once Devlin and her partner get to work, they quickly unearth secrets involving Birmingham’s most esteemed citizens. Each new layer of the investigation brings Devlin closer to the killer and the missing woman.

To Senior Midwife Lucy Ryuan, pregnancy is not an unusual condition - it's her life's work. But when two kidnappings and a vicious stabbing happen on her watch in a university hospital in Manhattan, her focus abruptly changes. Something has to be done, and Lucy is fearless enough to try. Rumors begin to swirl, blaming everyone from the Russian Mafia to an underground adoption network. Lucy teams up with a skeptical NYPD detective to solve the case, but the truth is far more twisted than a feisty single mom could ever have imagined.

Tech millionaire Miles Cookson has more money than he can ever spend and everything he could dream of - except time. He has recently been diagnosed with a terminal illness, and there is a 50 percent chance that it can be passed on to the next generation. For Miles, this means taking a long hard look at his past. Two decades ago, a young, struggling Miles was a sperm donor. Somewhere out there, he has kids - nine of them. And they might be about to inherit both the good and the bad from him - maybe his fortune, or maybe something much worse.

Olivia Bender designs exquisite home interiors that satisfy the most demanding clients. But her own deepest desire can’t be fulfilled by marble counters or the perfect rug. She desperately wants to be a mother. Fertility treatments and IVF keep failing. And just when she feels she’s at her lowest point, the police deliver shocking news to Olivia and her husband, Park. DNA results show that the prime suspect in a murder investigation is Park’s son. Olivia is relieved, knowing this is a mistake. Despite their desire, the Benders don’t have any children. Then comes the confession.

Thirteen years ago, Winter Black came home early from a sleepover to find her parents brutally murdered and her little brother gone — taken by a serial killer called The Preacher. Now a rookie FBI agent assigned to her first murder case, Winter has returned to the small Virginia town where she grew up. But when bones found by a hunter lead to the discovery of a secret burial ground containing the remains of children, the investigation suddenly hits close to home as the past and future collide with each new shocking discovery.

When crime reporter Jordan Manning leaves her hometown in Texas to take a job at a television station in Chicago, she’s one step closer to her dream: a coveted anchor chair on a national network. Jordan is smart and aggressive, with unabashed star-power, and often the only woman of color in the newsroom. Her signature? Arriving first on the scene—in impractical designer stilettos. Armed with a master’s degree in forensic science and impeccable instincts, Jordan has been able to balance her dueling motivations: breaking every big story—and giving a voice to the voiceless.

When a deadly bomb goes off during a climate change debate, librarian and event coordinator Jackie Santoro becomes the prime suspect. Her motive, according to Detective Avery Wick: to avenge the suicide of her prominent father, who was accused of crimes by a city councilman attending the event. Though Avery has doubts about Jackie’s guilt, he can’t exonerate her even after an extremist group takes responsibility for the bombing and continues to attack San Antonio’s treasured public spaces.

When her elderly patients start dying at home days after minor surgery, anesthesiologist Dr. Kate Downey wants to know why. The surgeon, not so much. “Old people die, that’s what they do,” is his response. When Kate presses, surgeon Charles Ricken places the blame squarely on her shoulders. Kate is currently on probation, and the chief of staff sides with the surgeon, leaving Kate to prove her innocence and save her own career. With her husband in a prolonged coma, it’s all she has left.

Former Chicago cop Selena "Lena" Dane has been going through the motions at her private investigation agency for years now. But then Lena learns that she's unexpectedly pregnant just as she takes on a heartbreaking new client: Nate Christianti, a fourteen-year-old boy in search of his biological father, Jason. Jason's disappearance isn't as clear-cut as everyone had thought, and Lena will need to follow his path of destruction halfway across the country to find Nate some answers.

Dr. Duncan Lathram is a brilliant plastic surgeon who recently invented a dissolving implant that allows incisions to heal without scarring. His unparalleled artistry in the operating room is the salvation of all the biggest power players in Washington, DC, whenever they need to be TV ready. Lathram appears to have it all, but something isn’t right....

Three years ago, a collision between a fast-moving freight train and a school bus full of kids led to devastation and grief on an unimaginable scale. But a fresh clue leads San Antonio police detective Amara Alvarez to the unlikely conclusion that one of the children may still be alive. If she's correct, everything law enforcement believes about the accident is a lie.

Luke has teamed up with Faith before, but he's not convinced she's up for the job, and she's not convinced he's telling her everything he knows. As more agents are targeted, Luke and Faith will have to learn to trust each other and work together to bring a killer to justice and prevent any more names from joining their fallen brothers and sisters on the Secret Service Wall of Honor.