A riveting exploration of the most difficult and important part of what doctors do, by Yale School of Medicine physician Dr. Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis", the inspiration for the hit Fox TV series House, M.D. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.

We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.

Scientists are confident that life exists elsewhere in the universe. Yet rather than taking a realistic approach to what aliens might be like, we imagine that life on other planets is the stuff of science fiction. The time has come to abandon our fantasies of space invaders and movie monsters and place our expectations on solid scientific footing. But short of alien's landing in New York City, how do we know what they are like?

In The Molecule of More: How a Single Chemical in Your Brain Drives Love, Sex, and Creativity—and will Determine the Fate of the Human Race, George Washington University professor and psychiatrist Daniel Z. Lieberman, MD, and Georgetown University lecturer Michael E. Long present a potentially life-changing proposal: Much of human life has an unconsidered component that explains an array of behaviors previously thought to be unrelated, including why winners cheat, why geniuses often suffer with mental illness, why nearly all diets fail, and more.

Not only can we not currently explain the origin of the universe, it is questionable we will ever be able to explain it. The notion that there are universes within particles, or that particles are conscious, is ascientific, as is the hypothesis that our universe is a computer simulation. On the other hand, the idea that the universe itself is conscious is difficult to rule out entirely.

You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. So what, exactly, is your immune system? In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes listeners on a journey through the fortress of the human body and its defenses.

Developing video games—hero's journey or fool's errand? The creative and technical logistics that go into building today's hottest games can be more harrowing and complex than the games themselves, often seeming like an endless maze or a bottomless abyss. In Blood, Sweat, and Pixels, Jason Schreier takes listeners on a fascinating odyssey behind the scenes of video game development, where the creator may be a team of 600 overworked underdogs or a solitary geek genius.

The number-one best-selling author of The Future of the Mind traverses the frontiers of astrophysics, artificial intelligence, and technology to offer a stunning vision of man's future in space, from settling Mars to traveling to distant galaxies. Formerly the domain of fiction, moving human civilization to the stars is increasingly becoming a scientific possibility - and a necessity. Whether in the near future due to climate change and the depletion of finite resources or in the distant future due to catastrophic cosmological events, humans will one day need to leave Earth.

A lifetime of adventures with bats around the world reveals why these special and imperiled creatures should be protected rather than feared.

Karl Deisseroth has spent his life pursuing truths about the human mind, both as a renowned clinical psychiatrist and as a researcher creating and developing the revolutionary field of optogenetics, which uses light to help decipher the brain’s workings. In Projections, he combines his knowledge of the brain’s inner circuitry with a deep empathy for his patients to examine what mental illness reveals about the human mind and the origin of human feelings - how the broken can illuminate the unbroken.

In 1637, one Dutchman paid as much for a single tulip bulb as the going price of a town house in Amsterdam. Three and a half centuries later, Amsterdam is once again the mecca for people who care passionately about one particular plant—though this time the obsessions revolves around the intoxicating effects of marijuana rather than the visual beauty of the tulip. How could flowers, of all things, become such objects of desire that they can drive men to financial ruin?

From a case of hysterical paralysis to a pregnancy puncturing a lung, twenty-five of the most thrilling medical mysteries known to man (and doctor)."Vital Signs," a popular column featured in Discover Magazine, has long been a favorite of readers, showcasing, each month, fascinating new tales of strange illnesses and diseases that baffle doctors and elude diagnosis. Each tale is true and borders on the unbelievable. It's no wonder that throughout the years the column has become an unofficial textbook for medical students, interns, doctors, and anyone interested in human illness and staying healthy.

A cataclysmic planetary phenomenon is gathering force deep within the Earth. The magnetic North Pole will eventually trade places with the South Pole. Satellite evidence suggests to some scientists that the move has already begun, but most still think it won't happen for many decades. All agree that it has happened many times before and will happen again. But this time it will be different. It will be a very bad day for modern civilization.

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

Anxiety affects more than forty million Americans—a number that continues to climb in the wake of the COVID-19 pandemic. While conventional medicine tends to view anxiety as a “neck-up” problem—that is, one of brain chemistry and psychology—the truth is that the origins of anxiety are rooted in the body. In The Anatomy of Anxiety, holistic psychiatrist Dr. Ellen Vora offers nothing less than a paradigm shift in our understanding of anxiety and mental health, suggesting that anxiety is not simply a brain disorder but a whole-body condition.

Over billions of years, ancient fish evolved to walk on land, reptiles transformed into birds that fly, and apelike primates evolved into humans that walk on two legs, talk, and write. For more than a century, paleontologists have traveled the globe to find fossils that show how such changes have happened.

Hope Jahren is an award-winning scientist, a brilliant writer, a passionate teacher, and one of the seven billion people with whom we share this earth. In The Story of More, she illuminates the link between human habits and our imperiled planet. In concise chapters, she takes us through the science behind the key inventions—from electric power to large-scale farming to automobiles—that, even as they help us, release greenhouse gases into the atmosphere like never before.

The Colorado River is an essential resource for a surprisingly large part of the United States, and every gallon that flows down it is owned or claimed by someone. David Owen traces all that water from the Colorado’s headwaters to its parched terminus, once a verdant wetland but now a million-acre desert. He takes listeners on an adventure downriver, along a labyrinth of waterways, reservoirs, power plants, farms, fracking sites, ghost towns, and RV parks, to the spot near the US-Mexico border where the river runs dry.

Carl Zimmer investigates one of the biggest questions of all: What is life? The answer seems obvious until you try to seriously answer it. Is the apple sitting on your kitchen counter alive, or is only the apple tree it came from deserving of the word? If we can’t answer that question here on Earth, how will we know when and if we discover alien life on other worlds? The question hangs over some of society’s most charged conflicts - whether a fertilized egg is a living person, for example, and when we ought to declare a person legally dead.

By the end of April 1945 in Germany, the Third Reich had fallen and invasion was underway. As the Red Army advanced, horrifying stories spread about the depravity of its soldiers. For many German people, there seemed to be nothing left but disgrace and despair. For tens of thousands of them, the only option was to choose death - for themselves and for their children.

You make hundreds of decisions every day, from what to eat for breakfast to how you should invest, and not one of them could be made without the essential component of emotion. It has long been held that thinking and feeling are separate and opposing forces in our behavior. But as Leonard Mlodinow, the best-selling author of Subliminal, tells us, extraordinary advances in psychology and neuroscience have proven that emotions are as critical to our well-being as is rational thinking.

After water and air, sand is the natural resource that we consume more than any other - even more than oil. Every concrete building and paved road on Earth, every computer screen and silicon chip, is made from sand. And, incredibly, we're running out of it. The World in a Grain is the compelling true story of the hugely important and diminishing natural resource that grows more essential every day, and of the people who mine it, sell it, build with it - and sometimes, even kill for it.

Locked in the silence and darkness of your skull, your brain fashions the rich narratives of your reality and your identity. Join renowned neuroscientist David Eagleman for a journey into the questions at the mysterious heart of our existence. What is reality? Who are “you”? How do you make decisions? Why does your brain need other people? How is technology poised to change what it means to be human?

One of our great contemporary scientists reveals the 10 profound insights that illuminate what everyone should know about the physical world.

A powerful new theory of human nature suggests that our secret to success as a species is our unique friendliness. For most of the approximately 300,000 years that Homo sapiens have existed, we have shared the planet with at least four other types of humans. All of these were smart, strong, and inventive. But around 50,000 years ago, Homo sapiens made a cognitive leap that gave us an edge over other species. What happened?

Born a privileged child of America’s Gilded Age, Marguerite Harrison rebelled against her mother’s ambitions, married the man she loved, was widowed at thirty-seven, and set off on a life of adventure. Hired as a society reporter, when America entered World War I she applied to Military Intelligence to work as a spy. Over a decade, Harrison’s mysterious adventures took her to Europe, Baghdad, and the Far East, as a socialite, secret agent, and documentary filmmaker. Janet Wallach captures Harrison’s daring and glamour in this stranger-than-fiction history of a woman drawn to the impossible.

The intellectual adventure story of the "double-slit" experiment, showing how a sunbeam split into two paths first challenged our understanding of light and then the nature of reality itself - and continues to almost 200 years later. Through Two Doors at Once celebrates the elegant simplicity of an iconic experiment and its profound reach. With his extraordinarily gifted eloquence, Anil Ananthaswamy travels around the world, through history and down to the smallest scales of physical reality we have yet fathomed. It is the most fantastic voyage you can take.

A groundbreaking guide to the surprising source of good health. Genetics and lifestyle are thought to be the two most important determinants of good health. But that is not the whole story. We have a second genome, our gut bacteria, that sets the dial on our bodies. Unlike our DNA, we can influence the gut bacteria, or microbiota, to optimize all aspects of our health. In The Good Gut, noted Stanford researchers Justin and Erica Sonnenburg investigate how the trillions of microbes that reside in our gastrointestinal tract help define us.

Vince Beiser explores the Achilles’ heel of “green power” and digital technology–that manufacturing computers, cell phones, electric cars, and other technologies demand skyrocketing amounts of lithium, copper, cobalt, and other materials. Around the world, businesses and governments are scrambling for new places and new ways to get those metals, at enormous cost to people and the planet. Beiser crisscrossed the world to talk to the people involved and report on the damage this race is inflicting, the ways it could get worse, and how we can minimize the damage.

Karen Fine always knew that she wanted to be a vet and wasn't going to let anything stop her: not her allergy to cats, and not the fact that in the '80s veterinary medicine was still a mostly male profession. Inspired by her grandfather, a compassionate doctor who paid house calls to all his (human) patients, Dr. Fine persevered, and brought her Oupa's principles into her own practice, which emphasizes the need to understand her patients’ stories to provide the best possible care.