Chemist Elizabeth Zott is not your average woman. In fact, Elizabeth Zott would be the first to point out that there is no such thing as an average woman. But it’s the early 1960s and her all-male team at Hastings Research Institute takes a very unscientific view of equality. Except for one: Calvin Evans; the lonely, brilliant, Nobel–prize nominated grudge-holder who falls in love with—of all things—her mind. True chemistry results.

In the spring of 2020, Lara’s three daughters return to the family's orchard in Northern Michigan. While picking cherries, they beg their mother to tell them the story of Peter Duke, a famous actor with whom she shared both a stage and a romance years before at a theater company called Tom Lake. As Lara recalls the past, her daughters examine their own lives and relationship with their mother, and are forced to reconsider the world and everything they thought they knew.

Diana O’Toole is perfectly on track. She will be married by thirty, done having kids by thirty-five, and move out to the New York City suburbs, all while climbing the professional ladder in the cutthroat art auction world. She’s an associate specialist at Sotheby’s now, but her boss has hinted at a promotion if she can close a deal with a high-profile client. She’s not engaged just yet, but she knows her boyfriend, Finn, a surgical resident, is about to propose on their romantic getaway to the Galápagos - days before her thirtieth birthday. Right on time.

William Waters grew up in a house silenced by tragedy, where his parents could hardly bear to look at him, much less love him—so when he meets the spirited and ambitious Julia Padavano in his freshman year of college, it’s as if the world has lit up around him. With Julia comes her family, as she and her three sisters are inseparable: Sylvie, the family’s dreamer, is happiest with her nose in a book; Cecelia is a free-spirited artist; and Emeline patiently takes care of them all.

Renu Amin always seemed perfect: doting husband, beautiful house, healthy sons. But as the one-year anniversary of her husband’s death approaches, Renu is binge-watching soap operas and simmering with old resentments. She can’t stop wondering if, thirty-five years ago, she chose the wrong life. In Los Angeles, her son, Akash, has everything he ever wanted, but as he tries to kickstart his songwriting career and commit to his boyfriend, he is haunted by the painful memories he fled a decade ago.

Jess needs a fresh start. She’s broke and alone, and she’s just left her job under less than ideal circumstances. Her half-brother Ben didn’t sound thrilled when she asked if she could crash with him for a bit, but he didn’t say no, and surely everything will look better from Paris. Only when she shows up – to find a very nice apartment, could Ben really have afforded this? – he’s not there.

Emma loves her husband Leo and their young daughter Ruby: she’d do anything for them. But almost everything she's told them about herself is a lie. And she might just have got away with it, if it weren’t for her husband’s job. Leo is an obituary writer; Emma a well-known marine biologist. When she suffers a serious illness, Leo copes by doing what he knows best – researching and writing about his wife’s life. But as he starts to unravel the truth, he discovers the woman he loves doesn’t really exist. Even her name isn’t real.

In June, 1954, eighteen-year-old Emmett Watson is driven home to Nebraska by the warden of the juvenile work farm where he has just served fifteen months for involuntary manslaughter. His mother long gone, his father recently deceased, and the family farm foreclosed upon by the bank, Emmett's intention is to pick up his eight-year-old brother, Billy, and head to California where they can start their lives anew. But when the warden drives away, Emmett discovers that two friends from the work farm have hidden themselves in the trunk of the warden's car.

Olivia McAfee knows what it feels like to start over. Her picture-perfect life—living in Boston, married to a brilliant cardiothoracic surgeon, raising their beautiful son, Asher—was upended when her husband revealed a darker side. She never imagined that she would end up back in her sleepy New Hampshire hometown, living in the house she grew up in and taking over her father’s beekeeping business. Lily Campanello is familiar with do-overs, too. When she and her mom relocate to Adams, New Hampshire, for her final year of high school, they both hope it will be a fresh start.

Mia, the irreverent, hyperanalytical twenty-year-old daughter, has an explanation for everything—which is why she isn’t initially concerned when her father and younger brother Eugene don’t return from a walk in a nearby park. They must have lost their phone. Or stopped for an errand somewhere. But by the time Mia’s brother runs through the front door bloody and alone, it becomes clear that the father in this tight-knit family is missing and the only witness is Eugene, who has the rare genetic condition Angelman syndrome and cannot speak.

Lucky Armstrong is a tough, talented grifter who has just pulled off a million-dollar heist with her boyfriend, Cary. She’s ready to start a brand-new life, with a new identity - when things go sideways. Lucky finds herself alone for the first time, navigating the world without the help of either her father or her boyfriend, the two figures from whom she’s learned the art of the scam. When she discovers that a lottery ticket she bought on a whim is worth millions, her elation is tempered by one big problem: Cashing in the winning ticket means she’ll be arrested for her crimes.

The British-born Punjabi Shergill sisters Rajni, Jezmeen, and Shirnia were never close and barely got along growing up and now have grown even further apart as adults. Rajni, a school principal, is a stickler for order. Jezmeen, a 30-year-old struggling actress, fears her big break may never come. Shirina, the peacemaking "good" sister, married into wealth and enjoys a picture-perfect life. On her deathbed, their mother voices one last wish: that her daughters will make a pilgrimage together to the Golden Temple in Amritsar to carry out her final rites.

London, 1925: In a world of townhomes and tennis matches, socialites and shooting parties, Miss Nan O’Dea became Archie Christie’s mistress, luring him away from his devoted and well-known wife, Agatha Christie. The question is, why? Why destroy another woman’s marriage, why hatch a plot years in the making, and why murder? How was Nan O’Dea so intricately tied to those 11 mysterious days that Agatha Christie went missing?

In present-day California, Eleanor Bennett’s death leaves behind a puzzling inheritance for her two children, Byron and Benny: a black cake, made from a family recipe with a long history, and a voice recording. In her message, Eleanor shares a tumultuous story about a headstrong young swimmer who escapes her island home under suspicion of murder. The heartbreaking tale Eleanor unfolds, the secrets she still holds back, and the mystery of a long-lost child challenge everything the siblings thought they knew about their lineage and themselves.

After her parents moved her and her brother to America, Preeti Desai never meant to tear her family apart. All she did was fall in love with a white Christian carnivore instead of a conventional Indian boy. Years later, with her parents not speaking to her and her controversial relationship in tatters, all Preeti has left is her career at a prestigious Los Angeles law firm. But when Preeti receives word of a terrible accident in the city where she was born, she returns to India, where she’ll have to face her estranged parents...and the complicated past they left behind.