The future looks bright for John and Ruby. John's business is growing, and they're talking about starting a family. But when Ruby receives a life-changing diagnosis, and insurance won't cover the treatment, John steals a customer's identity and files a false claim. The plan works perfectly - until the customer in question contacts John with a startling proposition. If John and Ruby play a little game he's devised, he won't report their fraud. The rules are simple: commit real crimes.

Charlie Giles is at the top of his game. An electronics superstar, he’s sold his startup company to a giant Boston firm, where he’s now a senior director. With his dog, Monte, at his side, Charlie is treated like a VIP everywhere he goes. Then one day, everything in Charlie’s neatly ordered world starts to go terrifyingly wrong. His prestigious job and his inventions are wrenched away from him. His family is targeted, and his former employers are dying gruesomely, picked off one by one. Every sign, every shred of evidence, points to Charlie as a cold-blooded killer.

Nine years after he left Shilo, New Hampshire, former Navy SEAL Tom Hawkins has moved back. It’s not an auspicious homecoming. Tom has returned to raise his teenage daughter, Jill, following the murder of his ex-wife, Kelly. Despite Tom’s efforts to stay close to Jill by coaching her high school soccer team, Kelly’s bitterness fractured their relationship. But together, they are on the mend, and life in Shilo is starting to shape up into something approaching normal. Normal doesn’t last long. Shilo’s police sergeant makes it clear that Tom is his chief suspect in Kelly’s death.

When President Geoffrey Hilliard’s son Cam, a 16-year-old chess champion, experiences extreme fatigue, moodiness, and an uncharacteristic violent outburst, doctors are quick to dismiss his troubles as teen angst. But Secret Service agent Karen Ray summons her physician ex-husband for a second opinion. Dr. Lee Blackwood’s concerns are dismissed by the president's team - until Cam gets sicker. Lee must make a diagnosis from a puzzling array of symptoms he's never seen before. His only clue is a patient named Susie Banks, a young musical prodigy who seems to be suffering from the same baffling condition as Cam.

Dr. Carrie Bryant's four years as a neurosurgical resident at White Memorial Hospital have earned her the respect and admiration from peers and staff alike. When given the chance of performing her first unsupervised brain surgery, Carrie jumps at the opportunity. What should have been a routine, hours-long operation turns horribly wrong and jeopardizes her patient's life. Emotionally and physically drained, Carrie is rushed back to the OR to assist in a second surgery.