Like millions of Americans, Dr. John VanDuyne is stunned to watch President Tom Winston announce his plans to legalize narcotics in a radical bid to destroy the power of the drug cartels. Especially since, as Winston’s personal physician and a government health spokesman, VanDuyne might have expected some prior warning. And now he’s going to be right in the firing line when the uproar begins. For President Winston, his daring plan could turn out to be political suicide. For VanDuvne, it’s going to be much worse than that.

After Brooklyn mob widow Rena Ruggiero hits her 80-year-old neighbor Enzio in the head with an ashtray when he makes an unwanted move on her, she embarks on a bizarre adventure. Taking off in Enzio’s ’62 Impala, she retreats to the Bronx home of her estranged daughter, Adrienne, and her granddaughter, Lucia, only to be turned away by Adrienne at the door. Their neighbor, Lacey “Wolfie” Wolfstein, a one-time Golden Age porn star and retired Florida Suncoast grifter, takes Rena in and befriends her.

Billy Summers is a man in a room with a gun. He’s a killer for hire and the best in the business. But he’ll do the job only if the target is a truly bad guy. And now Billy wants out. But first there is one last hit. Billy is among the best snipers in the world, a decorated Iraq war vet, a Houdini when it comes to vanishing after the job is done. So what could possibly go wrong?

In the middle of the night, in a house on a quiet street in suburban Minneapolis, intruders silently murder Luke Ellis' parents and load him into a black SUV. The operation takes less than two minutes. Luke will wake up at The Institute, in a room that looks just like his own, except there's no window. And outside his door are other doors, behind which are other kids with special talents - telekinesis and telepathy - who got to this place the same way Luke did: Kalisha, Nick, George, Iris, and 10-year-old Avery Dixon.

Ike Randolph has been out of jail for fifteen years, with not so much as a speeding ticket in all that time. But a Black man with cops at the door knows to be afraid. The last thing he expects to hear is that his son Isiah has been murdered, along with Isiah’s white husband, Derek. Ike had never fully accepted his son but is devastated by his loss. Derek’s father Buddy Lee was almost as ashamed of Derek for being gay as Derek was ashamed his father was a criminal. Buddy Lee still has contacts in the underworld, though, and he wants to know who killed his boy.

Matthew Worth is a mess. Somewhere between a good cop and a bad screwup, he botched a marriage and a career. His fellow officers think he’s a joke. His commanders are tired of cutting him breaks. Even his wife has left him for a flashy homicide detective. Busted to night patrol at a robbery-prone Omaha supermarket, Worth is doing time, wearing his uniform and asking shoppers if they want paper or plastic. If that isn’t enough, he suspects he might be falling for Gwen, the shy checkout girl who may be an even bigger mess than he is. It couldn’t get any worse. Until it does.

Beauregard "Bug" Montage is an honest mechanic, a loving husband, and a hardworking dad. Bug knows there's no future in the man he used to be: Known from the hills of North Carolina to the beaches of Florida as the best wheelman on the East Coast. He thought he'd left all that behind him, but as his carefully built new life begins to crumble, he finds himself drawn inexorably back into a world of blood and bullets. When a smooth-talking former associate comes calling with a can't-miss jewelry store heist, Bug feels he has no choice but to get back in the driver's seat.

Divorced. Broke. Living with a pack of elderly roommates. And those hallucinations she’s diligently ignoring? Her tarot card-dealing mom is convinced they’re clairvoyant visions. Just when things can’t get worse, a so-hot-it-should-be-illegal private investigator shows up on her doorstep looking for a neighbor...who turns up murdered.

In the summer of 1974 a heatwave blankets Boston and Mary Pat Fennessey is trying to stay one step ahead of the bill collectors. Mary Pat has lived her entire life in the projects of “Southie,” the Irish American enclave that stubbornly adheres to tradition and stands proudly apart. One night Mary Pat’s teenage daughter Jules stays out late and doesn’t come home. That same evening, a young Black man is found dead, struck by a subway train under mysterious circumstances. Mary Pat, propelled by a desperate search for her daughter, begins turning over stones best left untouched.

Henry “call me Hank” Thompson used to play California baseball. Now he tends to a bar on Manhattan’s Lower East Side. When two Russians in tracksuits beat Hank to a pulp, he gets the clue: someone wants something from him. He just doesn’t know what it is, where it is, or how to make them understand he doesn’t have it. Within twenty-four hours, Hank is running over rooftops, playing hide-and-seek with the NYPD, riding the subway with a dead man at his side, and counting a whole lot of cash on a concrete floor. All because of some Russian hoods and a flat-out freakshow of goons.

Whether it's working at his cousin's funeral home or tossing around the local riffraff at his favorite bar, Nathan Waymaker is a man who knows how to handle the bodies. A former marine and sheriff's deputy, Nathan has built a reputation in his small Southern town as a man who can help when all other avenues have been exhausted. When a beloved local minister is found dead, his parishioners ask Nathan to make sure the death isn’t swept under the rug.

Dane Kirby is a broken man and no stranger to tragedy. As a life-long resident and ex-arson investigator for McFalls County, Dane has lived his life in one of the most chaotic and crime-ridden regions of the south. When he gets called in to consult on a brutal murder in a Jacksonville, Florida, motel room, he and his FBI counterpart, Special Agent Roselita Velasquez, begin an investigation that leads them back to the criminal circles of his own backyard.

Dr. Blair Harbour, once a wealthy, respected pediatric surgeon, is now an ex-con down on her luck. She's determined to keep her nose clean and win back custody of her son. But when her former cellmate begs for help to find her missing daughter, Blair is compelled to put her new-found freedom on the line. Detective Jessica Sanchez has always had a difficult relationship with the LAPD. And her inheritance of a multi-million dollar mansion as a reward for catching a killer has just made her police enemy number one.

Shirley Lyle hooks for a living. She’s a big girl who keeps her profile low. But when a drug lord and his son toss her trailer, she adds a couple letters to her name. Now, she’s killed the drug lord’s son and two meth zombies. Fed up, ready to set fire to her past, her job - and her trailer - she’s dragged back into the role she’s forsworn by a man who presses her buttons with a hammer. Shirley realizes she’ll never be more than a 400-pound hooker. But when her partner-in-revolution, Ulyana the Ukrainian stripper, disappears, Shirley puts flame to fuse.

Teancum Leon, who goes by Tean, is a wildlife veterinarian. His life has settled into a holding pattern: He loves his job, he hates first dates, and he only occasionally has to deal with his neighbor Mrs. Wish’s cat-related disasters. All of that changes, though, when a man appears in his office, asking for help to find his brother. Jem is convinced that something bad has happened to Benny, and he thinks Tean might be able to help. Tean isn’t sure, but he’s willing to try. After all, Jem is charming and sweet and surprisingly vulnerable. Oh. And hot.