Death is reporter Jack McEvoy's beat: his calling, his obsession. But this time, death brings McEvoy the story he never wanted to write - and the mystery he desperately needs to solve. A serial killer of unprecedented savagery and cunning is at large. His targets: homicide cops, each haunted by a murder case he couldn't crack. The killer's calling card: a quotation from the works of Edgar Allan Poe. His latest victim is McEvoy's own brother. And his last...may be McEvoy himself.

After his December 2003 arrest, registered nurse Charlie Cullen was quickly dubbed "The Angel of Death" by the media. But Cullen was no mercy killer, nor was he a simple monster. He was a favorite son, husband, beloved father, best friend, and celebrated caregiver. Implicated in the deaths of as many as 300 patients, he was also perhaps the most prolific serial killer in American history.

Not far from Washington, D.C., in a wooded area of Northern Virginia, a small house at the end of a gravel road serves a secret purpose. With its sophisticated security apparatus and hidden miniaturized cameras, it is being used by the FBI to interview one of the most important witnesses the agency has ever had, a young woman with an incredible story to tell. But a few people know about the secret meeting. And for them, a violent drama is about to begin.

Dr. Eric Parrish is the chief of the psychiatric unit at Havemeyer General Hospital outside of Philadelphia. Recently separated from his wife, Alice, he is doing his best as a single dad to his seven-year-old daughter, Hannah. His work seems to be going better than his homelife, however. His unit at the hospital has just been named number two in the country and, Eric has a devoted staff of doctors and nurses who are as caring as he is. But when he takes on a new patient, Eric's entire world begins to crumble.

Pia Grazdani is an exceptional yet aloof medical student working closely with Columbia University Medical Center's premier scientist on cutting-edge research that could revolutionize health care by creating replacement organs for critically ill patients. Thorough her work with the brilliant molecular geneticist Dr. Tobias Rothman, Pia knows she will be given the chance to fulfill her ambition to participate in medical discoveries that can help millions while bringing her a measure of personal peace.

George Wilson, M.D., a radiology resident in Los Angeles, is about to enter a profession on the brink of an enormous paradigm shift, foreshadowing a vastly different role for doctors everywhere. The smartphone is poised to take on a new role in medicine, no longer as a mere medical app but rather as a fully customizable personal physician capable of diagnosing and treating even better than the real thing. It is called iDoc. George's initial collision with this incredible innovation is devastating.

The center of world power has just been jolted when the vice president of the US is poisoned to death. During the ensuing investigation, FBI Agent Tim Lane discovers something that will send shock waves around the globe. Meanwhile, on his way back to Stanford, college freshman Ryan Lane accidentally takes his brother’s duffel, his secret duffel. Suddenly, a swarm of assassins, terrorists, and rogue federal agents are after what Ryan has and what he may now know, propelling him into a desperate search for his brother, who has mysteriously disappeared.

Remy Stanton is an ambitious corporate strategist who intervenes in an armed robbery and saves two lives, but is nearly killed in the process. When he wakes in the hospital, he learns one of the intended victims was Alena Griggs, the daughter and sole heir of Rawson Griggs, a brilliant, brash billionaire - and one of the most powerful men in the world. Rawson Griggs is about to announce a run for President of the United States, and he offers Remy a position in his campaign. Suddenly Remy finds himself thrust into the most controversial Presidential election in history.

Newly minted chief resident at Boston Memorial Hospital Noah Rothauser is swamped in his new position, from managing the surgical schedules to dealing with the fallouts from patient deaths. Known for its medical advances, the famed teaching hospital has fitted several ORs as "hybrid operating rooms of the future" - an improvement that seems positive until an anesthesia error during a routine procedure results in the death of an otherwise healthy man.

Harmony House is more than a “special place for special people.” It’s a think tank where high-functioning autistic savants harness their unique abilities for the benefit of society. Resident Eddie Parks’s contribution: an “echo box” that can re-create never-recorded sounds using acoustic archeology. All Eddie wants is to hear his late mother’s voice. But what he’s created is inadvertently posing a threat to national security. To Harmony House’s shadowy government backers and radical extremists, the echo box is the ultimate intelligence asset - an end to the very concept of secrecy.

When President Geoffrey Hilliard’s son Cam, a 16-year-old chess champion, experiences extreme fatigue, moodiness, and an uncharacteristic violent outburst, doctors are quick to dismiss his troubles as teen angst. But Secret Service agent Karen Ray summons her physician ex-husband for a second opinion. Dr. Lee Blackwood’s concerns are dismissed by the president's team - until Cam gets sicker. Lee must make a diagnosis from a puzzling array of symptoms he's never seen before. His only clue is a patient named Susie Banks, a young musical prodigy who seems to be suffering from the same baffling condition as Cam.

A killer is putting the mangled, lifeless bodies of prostitutes on display in sleepy Northeast Tennessee. The murderous spree is accelerating. Two detectives, Lukas Miller from Johnson City and Brooke Stevens from Kingsport, have been assigned to hunt the killer down and stop him. Miller and Stevens are considered the best in their respective departments, and although they've never met, their superiors order them to work together in a coordinated effort to put an end to the violence as quickly as possible. Their reputations, and perhaps their careers, are on the line.

In Tehran, while hiding out from the Iranian secret police, CIA officer, Titus Ray, finds shelter with a group of Iranian Christians. Compelled by their unwavering faith, the battle-hardened agent becomes a believer shortly before they smuggle him out of Iran to freedom in Turkey. Returning to the States, he discovers his Iranian mission failed because of political infighting within the Agency. After delivering a scathing indictment against the Deputy Director of Operations, he's forced to take a year's medical leave in Oklahoma.

Meet Katie Reid, a young woman with a good job and a good life, until she discovers it was all a lie. Now, her desperate search for the truth begins and it will change her forever. Compelled to dig into a past no one wants to relive, Katie soon turns to Detective Marshall Avery. He is the only one willing to give her the resources she needs to find answers, but those answers could come at a steep price. When her search breathes new life into an old monster.

When private detective Dana Cutler is hired by an attorney with powerful political connections, the assignment seems simple enough: follow a pretty college student named Charlotte Walsh and report on where she goes and whom she sees. But then the unexpected happens.