Alice Love is 29, crazy about her husband, and pregnant with her first child. So imagine Alice’s surprise when she comes to on the floor of a gym and is whisked off to the hospital, where she discovers the honeymoon is truly over - she’s getting divorced, she has three kids, and she’s actually 39 years old. Alice must reconstruct the events of a lost decade and find out whether it’s possible to reconstruct her life at the same time.

Madeline is a force to be reckoned with. She’s funny, biting, and passionate; she remembers everything and forgives no one. Celeste is the kind of beautiful woman who makes the world stop and stare, but she is paying a price for the illusion of perfection. New to town, single mom Jane is so young that another mother mistakes her for a nanny. She comes with a mysterious past and a sadness beyond her years. These three women are at different crossroads, but they will all wind up in the same shocking place.

Imagine that your husband wrote you a letter, to be opened after his death. Imagine, too, that the letter contains his deepest, darkest secret - something with the potential to destroy not just the life you built together, but the lives of others as well. Imagine, then, that you stumble across that letter while your husband is still very much alive....

Sam and Clementine have a wonderful, albeit, busy life: they have two little girls, Sam has just started a new dream job, and Clementine, a cellist, is busy preparing for the audition of a lifetime. If there’s anything they can count on, it’s each other. Clementine and Erika are each other’s oldest friends. A single look between them can convey an entire conversation. But theirs is a complicated relationship, so when Erika mentions a last minute invitation to a barbecue with her neighbors, Tiffany and Vid, Clementine and Sam don’t hesitate.

Ellen O’Farrell is a professional hypnotherapist who works out of the eccentric beachfront home she inherited from her grandparents. It’s a nice life, except for her tumultuous relationship history. She’s stoic about it, but at this point, Ellen wouldn’t mind a lasting one. When she meets Patrick, she’s optimistic. He’s attractive, single, employed, and best of all, he seems to like her back. Then comes that dreaded moment: He thinks they should have a talk. Braced for the worst, Ellen is pleasantly surprised.

He was the first person to inspire her, to move her, to truly understand her. Was he meant to be the last? Lucy is faced with a life-altering choice. But before she can make her decision, she must start her story - their story - at the very beginning. Lucy and Gabe meet as seniors at Columbia University on a day that changes both of their lives forever. Together, they decide they want their lives to mean something, to matter. When they meet again a year later, it seems fated - perhaps they'll find life's meaning in each other.

Maddy is a devoted stay-at-home wife and mother, host of excellent parties, giver of thoughtful gifts, and bestower of a searingly perceptive piece of advice or two. She is the cornerstone of her family, a true matriarch...until she commits suicide, leaving her husband Brady and teenage daughter Eve heartbroken and reeling, wondering what happened. How could the exuberant, exacting woman they loved disappear so abruptly, seemingly without reason, from their lives? How they can possibly continue without her?

Caroline Murphy swore she'd never set foot back in the small Southern town of Peachtree Bluff; she was a New York girl born and bred and the worst day of her life was when, in the wake of her father's death, her mother selfishly forced her to move - during her senior year of high school, no less - back to that hick-infested rat trap where she'd spent her childhood summers.

From marriage, infidelity, and the mayhem of motherhood to scandal, tragedy, and illness - three women seek peace and comfort in Nantucket as they cope with life's challenges. Three women - burdened with small children, unwieldy straw hats, and some obvious emotional issues - tumble onto the Nantucket airport tarmac one hot June day. Vicki is trying to sort through the news that she has a serious illness. Her sister, Brenda, has just left her job after being caught in an affair with a student. And their friend Melanie, after seven failed in vitro attempts, is pregnant at last.

When Sarah meets Eddie, they connect instantly and fall in love. To Sarah, it seems as though her life has finally begun. And it's mutual: It's as though Eddie has been waiting for her, too. Sarah has never been so certain of anything. So when Eddie leaves for a long-booked vacation and promises to call from the airport, she has no cause to doubt him. But he doesn't call. Sarah's friends tell her to forget about him, but she can't. She knows something's happened - there must be an explanation.

Ellen and Andy's first year of marriage doesn't just seem perfect, it is perfect. There is no question how deep their devotion is, and how naturally they bring out the best in each other. But one fateful afternoon, Ellen runs into Leo for the first time in eight years. Leo, the one who brought out the worst in her. Leo, the one who left her heartbroken with no explanation. Leo, the one she could never quite forget. When his reappearance ignites long-dormant emotions, Ellen begins to question whether the life she's living is the one she's meant to live.

When an explosion rips apart a Chicago building, the lives of three women are forever altered. A year later, Cecily is in mourning. She was supposed to be in the building that day. Instead, she stood on the street and witnessed it going down, with her husband and best friend inside. Kate, now living thousands of miles away, fled the disaster and is hoping that her past won’t catch up with her. And Franny, a young woman in search of her birth mother, watched the horror unfold on the morning news, knowing that the woman she was so desperate to reconnect with was in the building.

When struggling novelist James Hernandez meets poet Louisa "Lou" Bell, he's sure he's just found the love of his life. There's just one problem: she's engaged to his oldest friend, Rob. So James toasts their union and swallows his desire. As the years pass, James's dreams always seem just out of reach - he can't finish that novel, can't mend his relationship with his father, can't fully commit to a romantic relationship. He just can't move on.

In all her life, Eustacia "Taisy" Cleary has given her heart to only three men: her first love, Ben Ransom; her twin brother, Marcus; and Wilson Cleary - professor, inventor, philanderer, self-made millionaire, brilliant man, breathtaking jerk, her father. Seventeen years ago Wilson ditched his first family for Caroline, a beautiful young sculptor. In all that time, Taisy's family has seen Wilson, Caroline, and their daughter, Willow, only once.

It’s been six years since Pen Calloway watched her best friends walk out of her life. And through the birth of her daughter, the death of her father, and the vicissitudes of single motherhood, she has never stopped missing them. Pen, Cat, and Will met on their first day of college and formed what seemed like a magical and lifelong bond, only to see their friendship break apart amid the realities of adulthood. When, after years of silence, Cat - the bewitching, charismatic center of their group - e-mails Pen and Will with an urgent request to meet at their college reunion, they can’t refuse.