
A Fatal Inheritance
How a Family Misfortune Revealed a Deadly Medical Mystery
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Narrated by:
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Roger Wayne
About this listen
Long-listed, BookPage Best Books of the Year, 2024
National Book Critics Circle Award nominee, 2024
Long-listed, Amazon.com Best Books of the Year, 2024
Long-listed, NPR Best Book of the Year, 2024
"Listeners will find A Fatal Inheritance to be an effective overview of research on cancer and hereditary predisposition, one that achieves serious investigation while remaining intensely human.”—BookPage
Weaving his own moving family story with a sweeping history of cancer research, Lawrence Ingrassia delivers an intimate, gripping tale that sits at the intersection of memoir and medical thriller
Ingrassia lost his mother, two sisters, brother, and nephew to cancer—different cancers developing at different points throughout their lives. And while highly unusual, his family is not the only one to wonder whether their heartbreak is the result of unbelievable bad luck, or if there might be another explanation.
Through meticulous research and riveting storytelling, Ingrassia takes us from the 1960s—when Dr. Frederick Pei Li and Dr. Joseph Fraumeni Jr. first met, not yet knowing that they would help make a groundbreaking discovery that would affect cancer patients for decades to come—to present day, as Ingrassia and countless others continue to unpack and build upon Li and Fraumeni’s initial discoveries, and to understand what this means for their families.
In the face of seemingly unbearable loss, Ingrassia holds onto hope. He urges us to “fight like Charlie,” his nephew who battled cancer his entire life starting with a rare tumor in his cheek at the age of two—and to look toward the future, as gene sequencing, screening protocols, CRISPR gene editing, and other developing technologies may continue to extend lifespans and perhaps, one day, even offer cures.
A Macmillan Audio production from Henry Holt & Company.
©2024 Lawrence Ingrassia (P)2024 Macmillan AudioListeners also enjoyed...
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Critic reviews
“A Fatal Inheritance by Lawrence Ingrassia is a compelling personal chronicle of tragedy and triumph. It captures both the ineffable pain of families riddled with cancers and the remarkable research over the past half century by scientists determined to help them.”—Siddhartha Mukherjee, author of The Emperor of All Maladies: A Biography of Cancer
"When two young doctors came across a family riddled with cancer for generations, they wondered why and began a decades long search for the answer. In A Fatal Inheritance, a riveting narrative of their quest, Lawrence Ingrassia intertwines a deeply personal and tearful story of unbearable family loss with an inspiring story of scientific discovery that revolutionized the understanding and treatment of cancer."—Walter Isaacson, author of Elon Musk, The Code Breaker and Steve Jobs
"When Lawrence Ingrassia lost his mother, sisters, brother and nephew to cancer, was it appallingly bad luck, or was there a common cause? This is the story of a family tragedy, a medical mystery, and the painstaking work of insightful scientists. By turns heartbreaking and hopeful, A Fatal Inheritance is a story of mortal loss and human resilience."—Geraldine Brooks, author of Horse and March
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Most of us give little thought to the back of the book - it's just where you go to look things up. But as Dennis Duncan reveals in this delightful and witty history, hiding in plain sight is an unlikely realm of ambition and obsession, sparring and politicking, pleasure and play. In the pages of the index, we might find "Butchers, to be avoided", or "Cows that shite Fire", or even catch "Calvin in his chamber with a Nonne". Here, for the first time, is the secret world of the index: an unsung but extraordinary everyday tool, with an illustrious but little-known past.
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Maybe a book that should be read rather than listened to
- By Amazon Customer on 11-09-22
By: Dennis Duncan
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One Way Back
- A Memoir
- By: Christine Blasey Ford
- Narrated by: Christine Blasey Ford
- Length: 8 hrs and 44 mins
- Unabridged
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On September 27, 2018, Christine Blasey Ford testified before the Senate Judiciary Committee which was considering the nomination of Judge Brett Kavanaugh to the United States Supreme Court. She described an alleged sexual assault by the Supreme Court nominee that took place at a high school party in the 1980s. Her words and courage on that day provided some of the most credible and unforgettable testimony our country has ever witnessed. In One Way Back, Ford recounts the months she spent trying to get information into the right hands without exposing herself and her family to backlash.
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Waste of my good money..
- By william Story on 01-30-25
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Funny Farm
- My Unexpected Life with 600 Rescue Animals
- By: Laurie Zaleski
- Narrated by: Erin Moon
- Length: 8 hrs and 10 mins
- Unabridged
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Laurie Zaleski never aspired to run an animal rescue; that was her mother Annie’s dream. But from girlhood, Laurie was determined to make the dream come true. Thirty years later as a successful businesswoman, she did it, buying a 15-acre farm deep in the Pinelands of South Jersey. She was planning to relocate Annie and her caravan of ragtag rescues - horses and goats, dogs and cats, chickens and pigs - when Annie died, just two weeks before moving day. In her heartbreak, Laurie resolved to make her mother’s dream her own.
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Heartwarming
- By Petfan on 04-13-22
By: Laurie Zaleski
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On Trails
- An Exploration
- By: Robert Moor
- Narrated by: Robert Moor
- Length: 11 hrs and 53 mins
- Unabridged
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From a talent who’s been compared to Annie Dillard, Edward Abbey, David Quammen, and Jared Diamond, On Trails is a wondrous exploration of how trails help us understand the world—from invisible ant trails to hiking paths that span continents, from interstate highways to the Internet.
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Great to listen to while I was on the trail!
- By Ken Jacobsen on 09-24-24
By: Robert Moor
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The Treeline
- The Last Forest and the Future of Life on Earth
- By: Ben Rawlence
- Narrated by: Jamie Parker
- Length: 11 hrs and 59 mins
- Unabridged
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For the last 50 years, the trees of the boreal forest have been moving north. The Treeline takes us along this critical frontier of our warming planet from Norway to Siberia, Alaska to Greenland, to meet the scientists, residents, and trees confronting huge geological changes.
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A surprising find
- By BearheartRaven on 02-23-22
By: Ben Rawlence
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Interpretation of Cats
- Understanding the Psychology of Our Feline Companions
- By: Claude Béata
- Narrated by: David Watson, Neil Gardner
- Length: 7 hrs and 27 mins
- Unabridged
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Cats are mysterious creatures, and the relationship between humans and cats has never been simple. Curious and affectionate, independent and uninterested, predator and prey. Their true nature continues to elude us, and their subtle and complex behavioral problems can often seem unsolvable or incomprehensible. So, how can we tell if a cat is suffering? What are the root causes of feline aggression? And how can we treat patients who can’t speak for themselves?
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Wonderful insight
- By Tom C on 01-31-25
By: Claude Béata
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Nazi Wives
- The Women at the Top of Hitler's Germany
- By: James Wyllie
- Narrated by: Dalya Raphael
- Length: 9 hrs and 30 mins
- Unabridged
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Goering, Goebbels, Himmler, Heydrich, Hess, Bormann - names synonymous with power and influence in the Third Reich. Perhaps less familiar are Carin, Emmy, Magda, Margarete, Lina, Ilse, and Gerda. These are the women behind the infamous men - complex individuals with distinctive personalities who were captivated by Hitler and whose everyday lives were governed by Nazi ideology. Throughout the rise and fall of Nazism these women loved and lost, raised families, and quarreled with their husbands and each other, all the while jostling for position with the Fuhrer himself.
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Scary
- By Three River on 05-15-21
By: James Wyllie
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Deliberate Cruelty
- Truman Capote, the Millionaire's Wife, and the Murder of the Century
- By: Roseanne Montillo
- Narrated by: Mia Barron
- Length: 8 hrs and 22 mins
- Unabridged
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When Ann Woodward shot her husband, banking heir Billy Woodward, in the middle of the night in 1955, her life changed forever. Though she claimed she thought he was a prowler, few believed the woman who had risen from charismatic showgirl to popular socialite. Everyone had something to say about the scorching scandal afflicting one of the most rich and famous families of New York City, but no one was more obsessed with the tale than Truman Capote.
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offensive narration
- By GM on 05-12-23
What listeners say about A Fatal Inheritance
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- Avid reader
- 05-17-24
Powerful story told incredibly well
Cancer decimated the author's family, taking lives way too soon, way too often, as he recounts in this book. But this story is much bigger than that. It's an incredibly powerful tale, not just of his family, but of other families, of posing questions and seeking answers. The lyrical prose of his retelling reads like a novel, while his decades as a journalist with the Wall Street Journal, the New York Times, and the Los Angeles Times come through in his detailed chronicling of the journey to unwrap the medical mystery of why his branch of the family (and so many other families) have been plagued by cancer. He skillfully distills medical research into everyday language so that readers can understand the science, while he pieces in families' stories so that they can empathize with the real-life toll cancer takes on so many.
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1 person found this helpful
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- Penelope
- 01-28-25
Fascinating medical nonfiction
Beautifully told story of families suffering from an inherited medical disorder and the researchers looking for the cause. The author uses the story of his own extended family and of several others to make this an unusually poignant and affecting book. The writing is outstanding and the narration is perfect.
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- Patricia Elizondo
- 07-05-24
Touching story with powerful lessons in hope.
This book provides an overview of the history of cancer diagnosis and treatments in a thoughtful way that is accessible to the non-scientific community. It sets the story context in the lives of cancer patients and their families. If you have a loved one who experienced cancer, you will cry painful tears and hopeful ones. I had to take breaks from the book, and each time it was easy to pick it back up. 🫶
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- Charlene
- 09-27-24
Absolutely beautifully written, fascinating, poignant, tragic and unforgettable.
I am an oncology nurse practitioner and the nerd in me adores a good biomedical documentary. This is more than that, it is an odyssey, and from the moment I started it, I could not put it down. The writing is also at a level that is understandable for people without backgrounds in science, nursing or medicine.
The history of the discovery of this particularly brutal heritable cancer syndrome is absolutely fascinating and Lawrence Engrassia skillfully weaves this together with stories from the initial families studied to ascertain the cause of the syndrome with stories of his own family. The details of these families repeated suffering as family member after family member is torn from them will forever be indelibly seared into my memory.
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- Mildred
- 01-08-25
The research
The personal facts of these families was so honest. The cancer research into the causes of cancer was very talented.
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- patricia Caballero Rodriguez
- 01-15-25
Full of emotion
Honest and straightforward prose , full of emotion. I felt the story and learned so much as well . Worth enduring the technical parts , overall enjoyed .
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- Katherine
- 05-20-24
An important book
This book blends the heart wrenching story of the Ingrassia family and how cancer shadowed three generations with chronicling the discovery of a genetic link. Superb story telling that keeps the reader engaged even as we can anticipate the devastating outcome. The science is conveyed clearly, so that non-scientists can grasp the progress to discovering the key mutation. Engrossing, illuminating and personal.
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- Linda Thompson
- 06-02-24
An Elucidating Memoir
Mr. Ingrassia has managed to write a reader friendly treatise on cancer research that reads like a novel. With a journalist’s talent for getting to the heart of a story in a clear and concise manner, he educates the reader on the process of medical research all the while interspersing the technical issues with the very touching human stories of families, including his own, plagued by recurring cancers. This memoir is truly a masterpiece of research by the author as well as a love letter to his family.
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- Lisa Ingrassia
- 06-07-24
Stunning story and great reporting
Beautifully reported book, wonderfully read by the narrator. The book intertwines the authors story of losing his entire family to cancer with the story of the epidemiologists who discovered a cancer gene, and the families they studied on their path. This book will be interesting to anyone who has lost a family member to cancer and grappled with fear and grief around that loss.
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- Margaret
- 03-23-25
Very Interesting and Informative
I found this audio book fascinating and easy to listen to. I highly recommend this book and author.
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