Eleanor Hamilton is happily married and mother to a beautiful four-year-old girl, Mabel. Her husband, Edward, is a leading light in the burgeoning Eugenics movement, which is designing the very ideas that will soon be embraced by Hitler. But when Mabel develops debilitating epileptic seizures and Eleanor discovers Edward has been keeping secrets, Eleanor's world fractures. In order to save her daughter, she takes matters into her own hands.

Irene Beltrán is a force to be reckoned with. As a magazine journalist, an unusual profession for a woman with her privileged upbringing, she is constantly challenging the oppressive regime. Her investigative partner is photographer Francisco Leal, the son of impoverished Spanish Marxist émigrés. Together, they are an inseparable team and - despite Irene’s engagement to an army captain - form a passionate connection.

Germany 1939 – To save her baby, Trudi Beck must hand her over to strangers who will take her across the sea to a foreign country. Trudi has already lost her husband to the Nazis, her stepsons are taking the train too. Walking away from the train station with empty arms is the hardest thing she's ever done. London 1939 – Newly married, Sally Matthews, is alone again. Her husband is away training for war, leaving her days and home empty. She volunteers to help with the children from the Kindertransport, becoming captivated by five-year-old Tom and his baby sister, Liesel.

Sophie Whalen is a young Irish immigrant so desperate to get out of a New York tenement that she answers a mail-order bride ad and agrees to marry a man she knows nothing about. San Francisco widower Martin Hocking proves to be as aloof as he is mesmerizingly handsome. Sophie quickly develops deep affection for Kat, Martin's silent five-year-old daughter, but Martin's odd behavior leaves her with the uneasy feeling that something about her newfound situation isn't right.

It's 1924 in Branchville, South Carolina, and three women have come to a crossroads. Gertrude, a mother of four, must make an unconscionable decision to save her daughters. Retta, a first-generation freed slave, comes to Gertrude's aid by watching her children, despite the gossip it causes in her community. Annie, the matriarch of the influential Coles family, offers Gertrude employment at her sewing circle, while facing problems of her own at home.

When Edward de Salis travels to America after the death of his first wife, he is astonished to find himself falling in love with Marguerite, a young woman many years his junior. Full of hope for the future, he returns to his Irish estate, Cashelmara, but in 19th-century Ireland - a country racked by poverty and famine - his family eventually becomes trapped in a sinister spiral of violence that Edward could never have foreseen.

Elisabetta, Marco, and Sandro grow up as the best of friends despite their differences. Elisabetta is a feisty beauty who dreams of becoming a novelist; Marco the brash and athletic son in a family of professional cyclists; and Sandro a Jewish mathematics prodigy, kind-hearted and thoughtful, the son of a lawyer and a doctor. Their friendship blossoms to love, with both Sandro and Marco hoping to win Elisabetta's heart.

Ernt Allbright, a former POW, comes home from the Vietnam war a changed and volatile man. When he loses yet another job, he makes an impulsive decision: He will move his family north, to Alaska, where they will live off the grid in America’s last true frontier.

Pregnant and still grieving the death of her fiancé, historian Megan Buchanan is forging ahead on a dream project: to restore to its original glory the landmark hunting lodge her own great-great-grandfather built on Virginia’s Eastern Shore. With the help of her fiancé’s caring best friend, it’s sure to draw much-needed tourist revenue to Cape Hudson, a town rich in southern history. However, it’s Spring House, the caretaker’s cottage on the grounds, that holds the most intriguing history for Megan.

Mickie Lambert creates “digital scrapbooks” for clients, ensuring that precious souvenirs aren’t forgotten or lost. When her latest client, Nadia Denham, a curio shop owner, dies from an apparent suicide, Mickie honors the old woman’s last wish and begins curating her peculiar objets d’art. A music box, a hair clip, a key chain - twelve mementos in all that must have meant so much to Nadia. But these tokens mean a lot to someone else, too. Mickie has been receiving threatening messages to leave Nadia’s past alone.

Johnny MacKinnon might be on the verge of losing it all. The ice factory he married into, which he's run for decades, is facing devastating OSHA fines following a mysterious accident and may have to close. The only hope for Johnny's livelihood is that someone in the community saw something, but no one seems to be coming forward. He hasn't spoken to his son Corran back in Scotland since Corran's heroin addiction finally drove Johnny to the breaking point.

For fourteen-year-old Leah Payne, life in her beloved coastal Carolina town is worlds away from the harsh realities of the day. Loyal to her lumberjack father, she knows only of the familiarity of her small community, the magic of the natural world, and the creative intuition that prompts her to march to the beat of her own drum. But when an accident takes her father's life, leaving her an orphan, Leah finds herself cast into a family of strangers whose welcoming façade hides a terrible secret.

One Sunday in the spring of 1988, a woman living on a reservation in North Dakota is attacked. The details of the crime are slow to surface as Geraldine Coutts is traumatized and reluctant to relive or reveal what happened, either to the police or to her husband, Bazil, and 13-year-old son, Joe. In one day, Joe's life is irrevocably transformed. He tries to heal his mother, but she will not leave her bed and slips into an abyss of solitude. Increasingly alone, Joe finds himself thrust prematurely into an adult world for which he is ill prepared.

When we first meet 14-year-old Susie Salmon, she is already in heaven. In the sweet, untroubled voice of a precocious teenage girl, Susie relates the awful events of her death and her own adjustment to the strange new place where she finds herself. With love, longing, and a growing understanding, Susie watches her family as they cope with their grief. This story of seemingly unbearable tragedy is transformed into a suspenseful and touching narrative about family, memory, love, heaven, and living.

North Dakota, late summer, 1999. Landreaux Iron stalks a deer along the edge of the property bordering his own. He shoots with easy confidence - but when the buck springs away, Landreaux realizes he's hit something else, a blur he saw as he squeezed the trigger. When he staggers closer, he realizes he has killed his neighbor's five-year-old son, Dusty Ravich.